Jun Sadoshima Pubmed Bibliography

2017

272. Sciarretta S, De Falco E, Frati G, Sadoshima J. How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium. Ann Transl Med. 2017 Feb;5(3):52. doi: 10.21037/atm.2017.01.52. PubMed PMID: 28251131; PubMed Central PMCID: PMC5326662.

271. Carrizzo A, Vecchione C, Damato A, di Nonno F, Ambrosio M, Pompeo F, Cappello mE, Capocci L, Peruzzi M, Valenti V, Biondi-Zoccai G, Marullo AG, Palmerio S, Carnevale R, Spinelli CC, Puca AA, Rubattu S, Volpe M, Sadoshima J, Frati G, Sciarretta S. Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction. J Am Heart Assoc. 2017 Feb 28;6(3). pii: e004746. doi: 10.1161/JAHA.116.004746. PubMed PMID: 28246076.

270. Saito T, Sadoshima J. Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System. Circ Res. 2017 Feb 17;120(4):610-612. doi:  10.1161/CIRCRESAHA.117.310450. PubMed PMID: 28209790; PubMed Central PMCID: PMC5319734.

269. Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn Ii GW, Sadoshima J, Ellisman MH, Gustafsson ÅB. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017 Jan 30;8:14050. doi: 10.1038/ncomms14050. PubMed PMID: 28134239; PubMed Central PMCID: PMC5290275.

268. Eisenberg T, et al. Dietary spermidine for lowering high blood pressure. Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24. PubMed PMID: 28118075; PubMed Central PMCID: PMC5381711.

2016

267. Nagarajan N, Oka S, Sadoshima J. Modulation of signaling mechanisms in the heart by thioredoxin 1. Free Radic Biol Med. 2016 Dec 16. pii: S0891-5849(16)31107-8. doi: 10.1016/j.freeradbiomed.2016.12.020. [Epub ahead of print] Review. PubMed PMID: 27993729.

266. Hsu YJ, Hsu SC, Hsu CP, Chen YH, Chang YL, Sadoshima J, Huang SM, Tsai CS, Lin CY. Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. Int J Cardiol. 2017 Feb 1;228:543-552. doi: 10.1016/j.ijcard.2016.11.247. Epub 2016 Nov 14. PubMed PMID: 27875732.

265. Eisenberg T, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. PubMed PMID: 27841876.

264. Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.

263. Bernardo BC, Ooi JY, Matsumoto A, Tham YK, Singla S, Kiriazis H, Patterson NL, Sadoshima J, Obad S, Lin RC, McMullen JR. Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs. J Physiol. 2016 Oct 15;594(20):5959-5974. doi: 10.1113/JP272512. PubMed PMID: 27270487.

262. Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J. Does Autophagy Mediate Cardiac Myocyte Death During Stress? Circ Res. 2016 Sep 30;119(8):893-5. doi: 10.1161/CIRCRESAHA.116.309765. PubMed PMID: 27688304.

261. Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H, Sadoshima J. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J Clin Invest. 2016 Sep 1;126(9):3403-16. doi: 10.1172/JCI85624. Epub 2016 Aug 15. PubMed PMID: 27525436; PubMed Central PMCID: PMC5004961.

260. Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, Takeuchi O, Sadoshima J, Egashira K. Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction. J Am Heart Assoc. 2016 Jul 22;5(7). pii: e003872. doi: 10.1161/JAHA.116.003872. PubMed PMID: 27451459; PubMed Central PMCID: PMC5015412.

259. Perez V, D'Annunzio V, Valdez LB, Zaobornyj T, Bombicino S, Mazo T, Carbajosa NL, Gironacci MM, Boveris A, Sadoshima J, Gelpi RJ. Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice. Antioxid Redox Signal. 2016 Jul 10;25(2):78-88. doi: 10.1089/ars.2015.6459. Epub 2016 May 6. PubMed PMID: 27000416.

258. Ikeda S, Sadoshima J. Regulation of Myocardial Cell Growth and Death by the Hippo Pathway. Circ J. 2016 Jun 24;80(7):1511-9. doi: 10.1253/circj.CJ-16-0476. Epub 2016 Jun 10. PubMed PMID: 27302848.

257. Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T. Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. J Cereb Blood Flow Metab. 2016 Jun;36(6):1143-54. doi: 10.1177/0271678X15606456. Epub 2015 Oct 13. PubMed PMID: 26661159; PubMed Central PMCID: PMC4908615.

256. Matsushima S, Zablocki D, Tsutsui H, Sadoshima J. Poldip2 negatively regulates matrix synthesis at focal adhesions. J Mol Cell Cardiol. 2016 May;94:10-2. doi: 10.1016/j.yjmcc.2016.03.001. Epub 2016 Mar 3. PubMed PMID: 26947023.

255. D Annunzio V, Perez V, Mazo T, Muñoz MC, Dominici FP, Carreras MC, Poderoso JJ, Sadoshima J, Gelpi RJ. Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1. Oncotarget. 2016 Mar 15;7(11):11889-98. doi: 10.18632/oncotarget.7726. PubMed PMID: 26933812; PubMed Central PMCID: PMC4914256.

254. Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. 2016 Mar;92:134-9. doi: 10.1016/j.yjmcc.2016.02.007. Epub 2016 Feb 9. PubMed PMID: 26868976.

253. Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016 Mar;92:30-40. doi: 10.1016/j.yjmcc.2016.01.020. Epub 2016 Jan 23. PubMed PMID: 26812119; PubMed Central PMCID: PMC5008453.

252. Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ Res. 2016 Aug 19;119(5):596-606. doi: 10.1161/CIRCRESAHA.116.308586. Epub 2016 Jul 11. PubMed PMID: 27402866; PubMed Central PMCID: PMC4992450.

251. Maejima Y, Isobe M, Sadoshima J. Regulation of autophagy by Beclin 1 in the heart. Journal of molecular and cellular cardiology. 2016; 95:19-25. NIHMSID: NIHMS778570 PubMed [journal] PMID: 26546165 PMCID: PMC4861696

250. Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK, Sadoshima J. Aging and Autophagy in the Heart. Circulation research. 2016; 118(10):1563-76. NIHMSID: NIHMS775896 PubMed [journal] PMID: 27174950 PMCID: PMC4869999

249. Nakamura M, Zhai P, Del Re DP, Maejima Y, Sadoshima J. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI insight. 2016; 1(5). NIHMSID: NIHMS781144 PubMed [journal] PMID:27218122 PMCID: PMC4869724

248. Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016; 133(13):1249-63. NIHMSID: NIHMS759008 PubMed [journal] PMID: 26915633, PMCID: PMC481167

247. Tong M, Sadoshima J. Mitochondrial autophagy in cardiomyopathy. Current opinion in genetics & development. 2016; 38:8-15. PubMed [journal] PMID: 27003723

2015

246. Maejima Y, Isobe M, Sadoshima J. Regulation of autophagy by Beclin 1 in the heart. Journal of molecular and cellular cardiology. 2015; PubMed [journal] PMID: 26546165

245. Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015 Dec;89(Pt B):185-94. doi: 10.1016/j.yjmcc.2015.11.013. Epub 2015 Nov 12. PubMed PMID: 26582463.

244. Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J, Shirokova N. Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy. Cardiovasc Res. 2015 Dec 1;108(3):324-34. doi: 10.1093/cvr/cvv238. Epub 2015 Oct 26. PubMed PMID: 26503985; PubMed Central PMCID: PMC4648202.

243. Liu T, Wu C, Jain MR, Nagarajan N, Yan L, Dai H, Cui C, Baykal A, Pan S, Ago T, Sadoshima J, Li H. Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta. 2015 Dec;1854(12):1816-22. doi: 10.1016/j.bbapap.2015.09.006. Epub 2015 Sep 26. PubMed PMID: 26410624; PubMed Central PMCID: PMC4721509.

242. Sciarretta S, Boppana VS, Umapathi M, Frati G, Sadoshima J. Boosting autophagy in the diabetic heart: a translational perspective. Cardiovasc Diagn Ther. 2015 Oct;5(5):394-402. doi: 10.3978/j.issn.2223-3652.2015.07.02. PubMed PMID: 26543826; PubMed Central PMCID: PMC4609904.

241. Oka S, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP, Sadoshima J. Peroxisome Proliferator Activated Receptor-α Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart. Circulation. Heart
failure. 2015; 8(6):1123-32. NIHMSID: NIHMS728912 PubMed [journal] PMID: 26443578, PMCID: PMC4651813

240. Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M, Sadoshima J. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 2015 Sep 2. pii: CIRCRESAHA.115.306624. [Epub ahead of print] PubMed PMID: 26333362.

239. Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015 Jul 31:ajpheart.00053.2015. doi: 10.1152/ajpheart.00053.2015. [Epub ahead of print] PubMed PMID: 26232232.

238. Ago T, Sadoshima J. From Contractile Enhancement to Pathological Hypertrophy: Angiotensin II-Induced Nox2-Mediated Reactive Oxygen Species. J Am Coll Cardiol. 2015 Jul 21;66(3):273-7. doi: 10.1016/j.jacc.2015.05.058. PubMed PMID: 26184621.

237. Zablocki D, Sadoshima J. Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out. Circulation. 2015 Jun 16;131(24):2097-100. doi: 10.1161/CIRCULATIONAHA.115.016978. Epub 2015 May 20. PubMed PMID: 25995314; PubMed Central PMCID: PMC4470784.

236. Saito T, Sadoshima J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res. 2015 Apr 10;116(8):1477-90. doi: 10.1161/CIRCRESAHA.116.303790. Review. PubMed PMID: 25858070; PubMed Central PMCID: PMC4419704.

235. Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep. 2015 Apr 7;11(1):125-36. doi: 10.1016/j.celrep.2015.03.010. Epub 2015 Apr 2. PubMed PMID: 25843706; PubMed Central PMCID: PMC4417361.

234. Sciarretta S, Yee D, Ammann P, Nagarajan N, Volpe M, Frati G, Sadoshima J. Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes. Clin Sci (Lond). 2015 Apr;128(7):387-403. doi: 10.1042/CS20140336. PubMed PMID: 25515000.\

233. Tzeng J, Byun J, Park JY, Yamamoto T, Schesing K, Tian B, Sadoshima J, Oka S. An Ideal PPAR Response Element Bound to and Activated by PPARα. PLoS One. 2015 Aug 4;10(8):e0134996. doi: 10.1371/journal.pone.0134996. eCollection 2015. PubMed PMID: 26241474; PubMed Central PMCID: PMC4524655.

2014

232. Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun. 2014 Dec 9;5:5705. doi: 10.1038/ncomms6705.PMID: 25489988 [PubMed - in process]

231. Nakamura M, Sadoshima J. Heart over mind: metabolic control of white adipose tissue and liver. EMBO Mol Med. 2014 Dec 3;6(12):1521-4. doi: 10.15252/emmm.201404749. No abstract available. PMID: 25471454 [PubMed - in process] Free Article

230. Moyzis AG, Sadoshima J, Gustafsson AB. Mending a Broken Heart: The Role of Mitophagy in Cardioprotection. Am J Physiol Heart Circ Physiol. 2014 Nov 26:ajpheart.00708.2014. doi: 10.1152/ajpheart.00708.2014. [Epub ahead of print]

229. Maejima Y, Chen Y, Isobe M, Gustafsson AB, Kitsis RN, Sadoshima J. Recent Progress in Research on Molecular Mechanisms of Autophagy in the Heart.Am J Physiol Heart Circ Physiol. 2014 Nov 1

228. Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J. Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress. Circ Res. 2014 Oct 20.

227. Chen L, Hou X, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen RA, Tong X.  Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines. Biochim Biophys Acta. 2014 Oct 11.

226. Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M, Sadoshima J. Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system. J Mol Cell Cardiol. 2014 Oct 7.

225. Hsu CP, Yamamoto T, Oka S, Sadoshima J. The function of nicotinamide phosphoribosyltransferase in the heart. DNA Repair (Amst). 2014
Sep 29.

224. Maejima Y, Sadoshima J. SUMOylation: a novel protein quality control modifier in the heart. Circ Res. 2014 Sep 26;115(8):686-9.

223. Wu C, Jain MR, Li Q, Oka SI, Li W, Kong AN, Nagarajan N, Sadoshima J, Simmons WJ, Li H. Identification of Novel Nuclear Targets of Human Thioredoxin 1. Mol Cell Proteomics. 2014 Sep 17. pii: mcp.M114.040931. [Epub ahead of print] PMID: 25231459 [PubMed - as supplied by publisher] Free Article

222. Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart. Oxid Med Cell Longev. 2014;2014:210934. Free PMC Article

221. Wackerhage H, Del Re DP, Judson RN, Sudol M, Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Sci Signal. 2014 Aug 5;7(337):re4.

220. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014 Jul 1;5:4241.         

219. Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, Schneider MD, Adelstein RS, Schmidt LS, Sadoshima J, Linehan WM. Hum Mol Genet. 2014 Jun 6.

218.  Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014 Jun 6;9(6):e98972. Free PMC Article

217. Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar R, Kho C. The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy. Antioxid Redox Signal. 2014 Jun 3.

216. Matsushima S, Tsutsui H, Sadoshima J. Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion. Trends Cardiovasc Med. 2014 Apr 1.

215. Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, Sadoshima J. Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL. Mol Cell. 2014 May 22;54(4):639-50.

214. Del Re DP, Sadoshima J. Elucidating ERK2 function in the heart. J Mol Cell Cardiol. 2014 Jul;72:336-8.

213. Sadoshima J, Weiss JN. Cardiac fibroblasts: the good, the bad, the ugly, the beautiful. J Mol Cell Cardiol. 2014 May;70:1.

212. Maejima Y, Usui S, Zhai P, Takamura M, Kaneko S, Zablocki D, Yokota M, Isobe M, Sadoshima J. Muscle-Specific RING Finger 1 Negatively Regulates Pathological Cardiac Hypertrophy Through Downregulation of Calcineurin A. Circ Heart Fail. 2014 May;7(3):479-90.

211. Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D, Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315. Free PMC Article

210. Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H, Sadoshima J. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014 Feb 4;19(2):232-45.

209. Sciarretta S, Volpe M, Sadoshima J. NOX4 regulates autophagy during energy deprivation. Autophagy. 2014 Apr;10(4):699-701.

208. Sciarretta S, Volpe M, Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 2014 Jan 31;114 (3):549-64.

207. Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J, Tan R. Elimination of NADPH oxidase activity promotes reductive stress and sensitizes he heart to ischemic njury. J Am Heart Assoc. 2014 Jan 27;3(1):e000555. doi: 10.1161/JAHA.113.000555.PMID: 24470522  Free PMC Article

2013

206. Sciarretta S, Yee D, Shenoy V, Nagarajan N, Sadoshima J. The Importance of Autophagy in Cardioprotection. High Blood Press Cardiovasc Prev. 2013 Nov 14. [Epub ahead of print] PMID: 24235024

205. Zablocki D, Sadoshima J. Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection. Circ Res. 2013 Nov 8;113 (11):1192-5. doi: 10.1161/CIRCRESAHA.113.302501. PMID: 24201113

204. Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians E, Benjamin I. Aggregate-prone R120GCRYAB triggers multifaceted modifications of the Thioredoxin System. Antioxid Redox Signal. 2013 Nov 1.  PMID: 24180415

203. Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest. 2013 Dec 2;123(12):5284-97. doi: 10.1172/JCI70877. Epub 2013 Nov 1. PMID: 24177425  Free PMC Article

202. Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013 Oct 20. doi: 10.1038/nm.3322.

201. Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA, Hardt SE. DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2B. PLoSOne. 2013 Sep 4;8(9):e70848. doi: 10.1371 /journal.pone.0070848.PMID: 24023715  Free PMC Article

200. Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Cardiovascular autophagy: Concepts, controversies and perspectives. Autophagy. 2013 Aug 14;9(10).

199.        Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M, Sadoshima J. Activation of Nox4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the PERK/eIF-2α/ATF4 Pathway. Circ Res. 2013 Sep 30.

198.        Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J, Hobbs AJ, Volpe M, Rubattu S. C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling. Circ Res. 2013 May 10;112(10):1355-64.                

197.        Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α. Circ Res. 2013 Apr 12;112(8):1135-49.

196.        Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):744-51. doi: 10.1161/ATVBAHA.112.300484. Epub 2013 Jan 24.

195.        Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y, Sadoshima J. Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart. PLoS One. 2013;8(1):e51632. doi: 10.1371/journal.pone.0051632. Epub 2013 Jan 7. PMID: 23308102  Free PMC Article

2012

194.        Del Re DP, Yang Y, Nakao N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D, Sadoshima J. Yes-associated protein isoform 1 (ap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem. 2012 Dec 30.  Free Article

193.        Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J. Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy. Circ Res. 2012 Dec 27.

192.        Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621. doi: 10.1371/journal.pone.0051621. Epub 2012 Dec 7.PMID: 23236519. Free Article

191.        Sadoshima J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544.

190.        Maejima Y, Galeotti J, Molkentin JD, Sadoshima J, Zhai P. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload. Am J Physiol Heart Circ Physiol. 2012 Oct;303(8):H979-88. Free PMC Article

189.        Oka S, Hsu CP, Sadoshima J. Regulation of cell survival and death by pyridine nucleotides. Circ Res. 2012 Aug 17;111(5):611-27.

188.        Nakamura M, Bhatnagar A, Sadoshima J. Overview of pyridine nucleotides review series. Circ Res. 2012 Aug 17;111(5):604-10.

187.        Zschauer TC, Matsushima S, Altschmied J, Shao D, Sadoshima J, Haendeler J. Interacting with Thioredoxin-1-Disease or No Disease?  Antioxid Redox Signal. 2012 Sep 24. [Epub ahead of print]

186.        Sciarretta S, Zhai P, Volpe M, Sadoshima J. Pharmacological modulation of autophagy during cardiac stress. J Cardiovasc Pharmacol. 2012 Sep;60(3):235-41.

185.        Del Re DP, Sadoshima J.RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression. Mol Biol Int. 2012;2012:154283. Epub 2012 Apr 10. Free PMC Article

184.        Sciarretta S, Volpe M, Sadoshima J.Is reactivation of autophagy a possible therapeutic solution for obesity and metabolic syndrome? Autophagy. 2012 Aug 1;8(8). [Epub ahead of print]

183.        Del Re DP, Sadoshima J.Enhancing the potential of cardiac progenitor cells: pushing forward with pim-1. Circ Res. 2012 Apr 27;110(9):1154-6.

182.        Zablocki D, Sadoshima J. Angiotensin II and Oxidative Stress in the Failing Heart. Antioxid Redox Signal. 2012 May 3. [Epub ahead of print]

181.        Oka SI, Zhai P, Alcendor R, Park JY, Tian B, Sadoshima J.Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart. Cell Cycle. 2012 Mar 1;11(5). [Epub ahead of print]

180.        Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J.Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012 Mar 6;125(9):1134-46. doi: 10.1161 /CIRCULATIONAHA.111.078212. Epub 2012 Jan 31. Circulation Editors' Pics  Free Article

179.        Messaoudi S, Zhang AD, Griol-Charhbili V, Escoubet B, Sadoshima J, Farman N, Jaisser F.The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. PLoS One. 2012;7(1):e30156. Epub 2012 Jan 23. Free PMC Article

178        Zhai P, Sadoshima J. Glycogen synthase kinase-3β controls autophagy during myocardial ischemia and reperfusion. Autophagy. 2012 Jan;8 (1):138-9. Epub 2012 Jan 1. Free PMC Article

177.        Shao D, Oka SI, Brady CD, Haendeler J, Eaton P, Sadoshima J. Redox modification of cell signaling in the cardiovascular system. J Mol Cell Cardiol. 2012 Mar;52(3):550-8. Epub 2011 Sep 17.

2011

176.        Sadoshima J, Hare JM. Meeting report for basic cardiovascular sciences 2011 scientific sessions: from concept to clinic: leading cardiovascular translational science. Circ Res. 2011 Nov 11;109(11):1204-5. Free Article

175.        Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B, Sadoshima J. PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway. Cell Metab. 2011 Nov 2;14(5):598-611. Free Article     Press Release 
  Summary in Japanese

174.        Sciarretta S, Zablocki D, Sadoshima J. New insights into the role and regulation of autophagy during myocardial ischemia. High Blood Pressure & Cardiovascular Prevention. 2011.

173.         Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS One. 2011;6(7):e22391. Free Article

172.        Zhai P, Sciarretta S, Galeotti J, Volpe M, Sadoshima J. Differential Roles of GSK-3{beta} During Myocardial Ischemia and Ischemia/Reperfusion. Circ Res. 2011 Aug 19;109(5):502-11. Epub 2011 Jul 7. Free Article

171.        Wu C, Parrott AM, Liu T, Jain MR, Yang Y, Sadoshima J, Li H. Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach. J Proteomics. 2011 Jun 17. Free Article

170.        Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T. Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. Circ J. 2011 Jul 25;75(8):1791-800. Epub 2011 Jun 15. Free Article

169.        Usui S, Maejima Y, Pain J, Hong C, Cho J, Park JY, Zablocki D, Tian B, Glass DJ, Sadoshima J. Endogenous Muscle Atrophy F-Box Mediates Pressure Overload-Induced Cardiac Hypertrophy Through Regulation of Nuclear Factor-{kappa}B. Circ Res. 2011 Jul 8;109(2):161-71. Epub 2011 May 26. Free Article

168.        Del Re DP, Sadoshima J. Is Raf1 a nexus for cardiac hypertrophic signaling in human disease? J Mol Cell Cardiol. 2011 Jul;51(1):1-3. Epub 2011 Apr 22.

167.        Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H. Thioredoxin 1-Mediated Post-Translational Modifications: Reduction. Transnitrosylation. Antioxid Redox Signal. 2011 Nov 1;15(9):2565-604. Epub 2011
Jun 8. Free Article

166.        Lin YR, Kim K, Yang Y, Ivessa A, Sadoshima J, Park Y. Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell. 2011 Jun;10(3):438-47. doi: 10.1111/j.1474-9726.2011.00678.x. Epub 2011 Mar 22.

165.        Sadoshima J. Sirt3 Targets mPTP and Prevents Aging in the Heart. AGING, 2011 Jan;3(1):12-3.  Free Article

164.        Zablocki D, Sadoshima J. Knocking Out Angiotensin II in the Heart. Curr Hypertens Rep. 2011 Apr;13(2):129-35. Review. Free Article

163.        Cho J, Zhai P, Maejima Y, Sadoshima J. Myocardial Injection With GSK-3{beta}-Overexpressing Bone Marrow-Derived Mesenchymal Stem Cells Attenuates Cardiac Dysfunction After Myocardial Infarction. Circ Res. 2011 Feb 18;108(4):478-89. Free Article. One of Ten Most Read Articles Published in Circulation Research in 2011

162.        Yamamoto T, Sadoshima J. Protection of the heart against ischemia/reperfusion by silent information regulator 1.Trends Cardiovasc Med. 2011 Jan;21(1):27-32. Free Article

161.        Maejima Y, Kuroda J, Matsushima S, Ago T, Sadoshima J. Regulation of myocardial growth and death by NADPH oxidase. J Mol Cell Cardiol. 2011 Mar;50(3):408-16. Epub 2011 Jan 6. Review. Free Article

2010

160.        Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T, Sadoshima J. The NADPH Oxidase Nox4 and Aging in the Heart. AGING (Albany NY). 2010 Dec;2(12):1012-6.Free Article

159.        Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. Circ Res. 2011 Feb 4;108(3):305-13. Free Article

158.        Sciarretta S, Hariharan N, Monden Y, Zablocki D, Sadoshima J. Is Autophagy in Response to Ischemia and Reperfusion Protective or Detrimental for the Heart? Pediatr Cardiol.  2011 Mar;32(3):275-81. Free Article

157.        Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, Del Re D, Bhaumik M, Yehia G, Sadoshima J, Fraidenraich D. Injection of Wild Type Embryonic Stem Cells into Mst1 Transgenic Blastocysts Prevents Adult-Onset Cardiomyopathy. Stem Cell Rev. 2010 Nov 18.  2011 Jun;7(2):326-30. Free Article

156.        Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. 2010. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Cir Res. Dec 10;107(12):1470-82. Free Article  <Best Manuscript Award>

155.        Matsushima S, Zablocki D, Sadoshima J. 2010. Application of Recombinant Thioredoxin1 for Treatment of Heart Disease. J Mol Cell Cardiol. Oct 16. Free Article

154.        Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Harinaran N, Shao D, Takagi H, Oka S, Sadoshima J. Silent information regulator 1  protects the heart from ischemia/reperfusion. Circulation, 2010. Nov 23;122(21):2170-82. Free Article

153.        Kajimoto K, Shao D, Takagi H, Maceri G, Zablocki D, Mukai H, Ono Y, Sadoshima J. 2010. Hypotonic swelling-induced activation of PKN mediates cell survival in cardiac myocytes. Am J Physiol Heart Circ Physiol  2011 Jan;300(1):H191-200. Free Article

152.        Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. 2010. Dietary restriction: standing up for sirtuins.  Science. 2010 Aug 27;329(5995):1012-3.

151.        Del Re, D.P., Matsuda, T., Zhai P., Gao S., Clark, G.J., van der Weyden, L., Sadoshima, J. 2010. Proapoptotic Rass1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J. Clin. Invest. Oct 1;120(10):3555-67. Free Article

150.        Kuroda, J., Ago, T., Matsushima, S., Zhai P., Scheneider, M.D., Sadoshima, J., 2010. Nox4 is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci USA. Aug 31;107(35):15565-70. Free Article

149.        Hariharan, N., Zhai, P., Sadoshima, J. 2010. Oxidative stress stimulates autophagic flux during ischemia/reperfution. Antioxid Redox Signal. Sep 2. Free Article

148.        Wu, C., Liu, T., Chen, W., Oka, S., Fu, C., Jain, M.R., Parrott, A.M., Baykal, A.T., Sadoshima, J., Li, H. 2010. Redox regulatory mechanism of transnytrosylation by thioredoxin. Mol Cell Proteomics. Oct;9(10):2262-75. Free Article

147.        Takagi, H., Hsu, C.-P., Kajimoto, K., Shao, D., Yang, Y., Maejima, Y., Zhai, P., Yeshia, G., Yamada, C., Zablocki, D., Sadoshima, J. 2010. Activation of PKN Mediates Survival of Cardiac Myocytes in the Heart During Ischemia/Reperfusion. Circ Res. Sep 3;107(5):642-9. Free Article

146.        Kuroda, J., Sadoshima, J. 2010. NADPH oxidase and cardiac failure. J Cardiovasc Transi Res. 3(4)314-20. Free Article

145.        Sciarretta, S., Sadoshima, J. 2010. New insights into the molecular phenotype of eccentric hypertrophy. J Mol Cell Cardiol. 49(2):153-4.  Free Article

144.        Haldar, S.M., Lu, Y., Jeyaraj, D., Kawanami, D., Cui, Y., Eapen, S.J., Hao, C., Li, Y., Doughman, Y.Q., Watanabe, M., Shimizu, K., Kuivaniemi, H., Sadoshima, J., Margulies, K.B., Cappola, T.P., Jain, M.K. 2010. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 7;2(26):26ra26. Free Article

143.        Zablocki, D., Sadoshima, J. 2010. The one-two punch: knocking out angiotensin II in the heart. J. Clin. Invest.120(4):1028-31. Free Article

142.        Ago, T., Yang, Y., Zhai, P., Sadoshima, J. 2010. Nifedipine Inhibits Cardiac Hypertrophy and Left Venticular Dyfunction in Response to Pressure Overload. J Cardiovascular Translational Research. 3(4):304-13. Free Article

141.        Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., Sadoshima, J. 2010. Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes. Cir Res. 106(7):1253-64. Free Article

140.       Chu, P.Y.,Mariani, J., Finch, S., McMullen, J.R., Sadoshima, J., 2010. Bone Marrow-Derived Cells Contribute of Fibrosis in the Chronically Failing Heart. Am J Pathol. 176(4):1735-42. Free Article

2009

139.       Hsu, C.P.,  Hariharan, N.,  Alcendor, R.N., Oka, S. and Sadoshima, J. 2009. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophasy 5(8):1229-31.       

138.       Cho, J.,  Rameshwar, P. and  Sadoshima, J. 2009. Distrinct Roles of GSK-3 and GSK-3β in Mediating Cardiomyocyte Differentiation in Murine Bone Marrow Delived Mesenchymal Stem Cells. J. Biol. Chem. 284(52):36647-58.

137.        Hu, C.L., Chandra, R., Ge, H., Pain, J., Yan, L., Babu, G.J., Depre, D., Iwatsubo, K., Ishikawa, Y., Sadohsima, J., Vatner, S.F., Vatner, D.F. 2009.   Adenylyl Cyclase Type 5 Protein Expression during Cardiac Development and Stress. Am J Physio Heart Circ Physiol. 297(5):H1776-82.

136.       Woodcock, E.A., Grubb, D.R., Flitz, T.M., Marasco, S., Luo, J., McLeod-Dryden, T.J., Kaye, D.M., Sadoshima, J., Du, X.J., Wong, C., McMullen, J.R., Dart, A.M. 2009 Selective Activation of the "B"splice Variant of Phospholipase Cbeta1 in Chronically Dilated Human Mouse Atria. J Mol Cell Cardiol  47 (5):676-83.

135.        Gelpi, R.J., Gao, S., Zhai, P., Yan, L., Hong, C., Danridge, L.A., Ge, H., Maejima, Y., Donato, M., Yokota, M., Molkentin, J.D., Vatner, D.E., Vatner, S. F., Sadoshima, J. 2009 Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol. 297(5):H1814-9.

134.        Del Re, D.P., Sadoshima, J. 2009. Optimizing cell-based therapy for cardiac regeneration. Circulation. 120(10):831-4.

133.        Pretorius, L., Du, X.J., Woodcock, E.A,. Kiriazis,H., Lin, R.C., Marasco, S., Medcalf, R.L., Ming, Z., Head, G.A., Tan, J.W., Cemerlang, N., Sadoshima, J., Shioi, T., Izumo, S., Lukoshkova, E.V., Dart, A.M., Jennings,G.L., McMullen, J.R. 2009. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am J Pathol. 175(3):998-1009.

132.         Hsu, C.P., Oka, S., Shao, D., Hariharan, N., Sadoshima, J. 2009. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 28;105(5):481-91.

131.         Wu, C., Yan, L., Depre, C., Dhar, S.K., Shen, Y.T., Sadoshima, J., Vatner, S.F., Vatner, D.E. Cytochrome C oxidase III as a mechanism for apoptosis in heart failure folloing myocardial infraction. Am J Physiol Cell Physiol. 297(4):C928-34.

130.        Bellis, A., Castaldo, D., Trimarco, V., Monti, M.G., Chivasso, P., Sadoshima, J., Trimarco, B., Morisco, C. 2009 Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late inschemic preconditioning. Arterioscler Thromb Vasc Biol. 29(8):1207-12.

129.        Yan, L., Sadoshima, J., Vatner, D.E., Vatner, S.F. 2009. Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy. 5(5): 709-12.

128.        Fu, C., Wu, C., Liu, T., Ago, T.,  Zhai, P., Sadoshima, J., Li, H. 2009. Elucidation of thioredoxin target protein networks in mouse. Mol Cell Proteomics. 8(7):1674-87.

127.        Oka, S., Ago, T., Kitazono,T., Zablocki, D., Sadoshima, J. 2009. The Role of Redox Modulation of Class II Histone Deacetylases in Mediating Pathological Cardiac Hypertrophy. Journal of Molecular Medicine. 87(8):785-91.

126.        Rane, S., He, M., Sayed, D., Vashistha, H., Malhotra, A., Sadoshima, J., Vatner, D.E., Vatner, S.F., Adbellatif, M. 2009. Downregulation of MiR- 199a Depresses Hypoxia-Inducible Factor-1{alpha} and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes. Circ Res. 104(7):879-
86

125.        Nishida, K., Kyoi, S., Yamaguchi, O., Sadoshima, J., Otsu, K. 2009. The role of autophagy in the heart. Cell Death Differ. 16(1):31-38.

124.        Perry, C.N., Kyoi, S., Hariharan, N., Takagi, H., Sadoshima, J., Gottlieb, R.A. 2009. Novel methods for measuring cardiac autophagy in vivo.  Methods in Enzymology. 453:325-342.

123.        Vatner, F.S., Yan, L., Ishikawa, Y., Vatner, E.D., and Sadoshima, J. 2009. Adenylyl Cyclase Type 5 Disruption Prolongs Longivity and Protects the Heart against Stress. Circ.J. 73(2):195-200.

2008

122.        Ago, T., Liu, T., Zhai, P., Chen, W., Li, H., Molkentin, J.D., Vatner, S.F., and Sadoshima, J. 2008. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 133:978-993.

121.        Fu, C., Hu, J., Liu, T., Ago, T., Sadoshima, J., and Li, H. 2008. Quantitative analysis of redox-sensitive proteome with DIGE and ICAT. J Proteome Res 7:3789-3802.

120.        Hsu, C.P., Odewale, I., Alcendor, R.R., and Sadoshima, J. 2008. Sirt1 protects the heart from aging and stress. Biol Chem 389:221-231.

119.        Klionsky, DJ et al. (JS is 168th out of 236 authors)  2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.

118.        Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto H, Takagi H, Tamamoti-Adachi T, Kitajima S, Sadoshima J. Phosphorylation of GSK-3
a is essential for myocyte proliferation in the heart under pressure overload. Proc Natl Acad Sci U S A. 2008; 105: 20900-20905.

117.        Matsui, Y., Kyoi, S., Takagi, H., Hsu, C.P., Hariharan, N., Ago, T., Vatner, S.F., and Sadoshima, J. 2008. Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy 4:409-415.

116.        Matsui, Y., Nakano, N., Shao, D., Gao, S., Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., Tao, W., Wagner, T., Nojima, H., and Sadoshima, J. 2008. Lats2 is a negative regulator of myocyte size in the heart. Circ Res 103:1309-1318.

115.       Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., and Sunagawa, K. 2008. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 28:1263-1269.

114.       Morisco, C., Marrone, C., Galeotti, J., Shao, D., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2008. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc Res 78:36-44.

113.        Ohtsubo, H., Ichiki, T., Imayama, I., Ono, H., Fukuyama, K., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K. 2008. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells. Biochem Biophys Res Commun 367:474-480.

112.        Sadoshima, J. 2008. The role of autophagy during ischemia/reperfusion. Autophagy 4:402-403.

111.        Shen, Y.T., Depre, C., Yan, L., Park, J.Y., Tian, B., Jain, K., Chen, L., Zhang, Y., Kudej, R.K., Zhao, X., Sadoshima, J., Vatner, D.E., and Vatner, S. F. 2008. Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation 118:1961-1969.

110.        Zhai, P., and Sadoshima, J. 2008. Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. Circ Res 103:910-913.

2007

109.        Ago, T., and Sadoshima, J. 2007. Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid Redox Signal 9:679-687.

108.        Alcendor, R.R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S.F., and Sadoshima, J. 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100:1512-1521.

107.        Hirotani, S., Zhai, P., Tomita, H., Galeotti, J., Marquez, J.P., Gao, S., Hong, C., Yatani, A., Avila, J., and Sadoshima, J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 101:1164-1174.

106.        Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., and Sadoshima, J. 2007. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100:914-922.

105.        Morisco, C., Marrone, C., Trimarco, V., Crispo, S., Monti, M.G., Sadoshima, J., and Trimarco, B. 2007. Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression. Cardiovasc Res 76:453-464.

104.        Nishizawa, T., Shen, Y.T., Rossi, F., Hong, C., Robbins, J., Ishikawa, Y., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2007. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am J Physiol Heart Circ Physiol 292:H971-975.

103.        Odashima, M., Usui, S., Takagi, H., Hong, C., Liu, J., Yokota, M., and Sadoshima, J. 2007. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res 100:1344-1352.

102.        Ohtsubo, H., Ichiki, T., Miyazaki, R., Inanaga, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K. 2007. Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell. Arterioscler Thromb Vasc Biol 27:1549-1555.

101.        Peter, P.S., Brady, J.E., Yan, L., Chen, W., Engelhardt, S., Wang, Y., Sadoshima, J., Vatner, S.F., and Vatner, D.E. 2007. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest 117:1335-1343.]

100.        Takagi, H., Matsui, Y., Hirotani, S., Sakoda, H., Asano, T., and Sadoshima, J. 2007. AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy 3:405-407.

99.        Takagi, H., Matsui, Y., and Sadoshima, J. 2007. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal 9:1373-1381.

98.        Yan, L., Vatner, D.E., O'Connor, J.P., Ivessa, A., Ge, H., Chen, W., Hirotani, S., Ishikawa, Y., Sadoshima, J., and Vatner, S.F. 2007. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130:247-258.

97.        Zhai, P., Gao, S., Holle, E., Yu, X., Yatani, A., Wagner, T., and Sadoshima, J. 2007. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. J Biol Chem 282:33181-33191.

2006

96.        Ago, T., and Sadoshima, J. 2006. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res 98:294-297.

95.        Ago, T., and Sadoshima, J. 2006. Thioredoxin and ventricular remodeling. J Mol Cell Cardiol 41:762-773.

94.        Ago, T., Yeh, I., Yamamoto, M., Schinke-Braun, M., Brown, J.A., Tian, B., and Sadoshima, J. 2006. Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart. Antioxid Redox Signal 8:1635-1650.

93.        Chen, I.Y., Lypowy, J., Pain, J., Sayed, D., Grinberg, S., Alcendor, R.R., Sadoshima, J., and Abdellatif, M. 2006. Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol Chem 281:19369-19377.

92.        Depre, C., Wang, Q., Yan, L., Hedhli, N., Peter, P., Chen, L., Hong, C., Hittinger, L., Ghaleh, B., Sadoshima, J., Vatner, D.E., Vatner, S.F., and Madura, K. 2006. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation 114:1821-1828.

91.        Liu, J., Sadoshima, J., Zhai, P., Hong, C., Yang, G., Chen, W., Yan, L., Wang, Y., Vatner, S.F., and Vatner, D.E. 2006. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. J Mol Cell Cardiol 41:680-688.

90.        Nishizawa, T., Vatner, S.F., Hong, C., Shen, Y.T., Hardt, S.E., Robbins, J., Ishikawa, Y., Sadoshima, J., and Vatner, D.E. 2006. Overexpressed cardiac Gsalpha in rabbits. J Mol Cell Cardiol 41:44-50.

89.        Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J.T., Puigserver, P., Sadoshima, J., Deng, H., Pedrini, S., Gandy, S., Sauve, A.A., and Pasinetti, G.M. 2006. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 281:21745-21754.

88.        Sadoshima, J. 2006. Redox regulation of growth and death in cardiac myocytes. Antioxid Redox Signal 8:1621-1624.

87.        Usui, S., Yeh, I., Tian, B., and Sadoshima, J. 2006. Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research. J Mol Cell Cardiol 41:219-222.

86.        Yan, L., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2006. Autophagy: a novel protective mechanism in chronic ischemia. Cell Cycle 5:1175-1177.

85.        Zebrowski, D.C., Alcendor, R.R., Kirshenbaum, L.A., and Sadoshima, J. 2006. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. J Mol Cell Cardiol 40:605-618.

84.        Zhai, P., Galeotti, J., Liu, J., Holle, E., Yu, X., Wagner, T., and Sadoshima, J. 2006. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ Res 99:528-536.

83.        Zhai P, Galeotti J, Sadoshima J. 2006. Unconventional signaling mechanisms mediated by the angiotensin II type I receptor in cardiovascular cell types. High Blood Pressure and Cardiovasc Prevention: 13, 143-150.

2005

82.        Ding, B., Abe, J., Wei, H., Huang, Q., Walsh, R.A., Molina, C.A., Zhao, A., Sadoshima, J., Blaxall, B.C., Berk, B.C., and Yan, C. 2005. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation 111:2469-2476.

81.        Ding, B., Abe, J., Wei, H., Xu, H., Che, W., Aizawa, T., Liu, W., Molina, C.A., Sadoshima, J., Blaxall, B.C., Berk, B.C., and Yan, C. 2005. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A
102:14771-14776.

80.        Hase, M., Depre, C., Vatner, S.F., and Sadoshima, J. 2005. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. Biochem J 388:475-483.

79.        Hirotani, S., and Sadoshima, J. 2005. Preconditioning effects of PKCdelta. J Mol Cell Cardiol 39:719-721.

78.        Morisco, C., Condorelli, G., Trimarco, V., Bellis, A., Marrone, C., Condorelli, G., Sadoshima, J., and Trimarco, B. 2005. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ Res 96:180-188.

77.        Ono, H., Ichiki, T., Ohtsubo, H., Fukuyama, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K. 2005. Critical role of Mst1 in vascular remodeling after injury. Arterioscler Thromb Vasc Biol 25:1871-1876.

76.        Yan, L., Vatner, D.E., Kim, S.J., Ge, H., Masurekar, M., Massover, W.H., Yang, G., Matsui, Y., Sadoshima, J., and Vatner, S.F. 2005. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A 102:13807-13812.

75.        Zhai, P., Yamamoto, M., Galeotti, J., Liu, J., Masurekar, M., Thaisz, J., Irie, K., Holle, E., Yu, X., Kupershmidt, S., Roden, D.M., Wagner, T., Yatani,A., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2005. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest 115:3045-3056.

2004

74.        Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., and Sadoshima, J. 2004. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 95:971-980.

73.        Hardt, S.E., and Sadoshima, J. 2004. Negative regulators of cardiac hypertrophy. Cardiovasc Res 63:500-509.

72.        Hardt, S.E., Tomita, H., Katus, H.A., and Sadoshima, J. 2004. Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy. Circ Res 94:926-935.

71.        Karoor, V., Vatner, S.F., Takagi, G., Yang, G., Thaisz, J., Sadoshima, J., and Vatner, D.E. 2004. Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure. J Mol Cell Cardiol 36:305-312.

70.        Kawabe, J., Okumura, S., Lee, M.C., Sadoshima, J., and Ishikawa, Y. 2004. Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 286:H1845-1852.

69.        Kim, T.G., Chen, J., Sadoshima, J., and Lee, Y. 2004. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol 24:10151-10160.

68.        Matsui, Y., and Sadoshima, J. 2004. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol 37:477-481.

2003

67.        Kim, S.J., Peppas, A., Hong, S.K., Yang, G., Huang, Y., Diaz, G., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2003. Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circ Res 92:1233-1239.

66.        Kim, Y.K., Kim, S.J., Yatani, A., Huang, Y., Castelli, G., Vatner, D.E., Liu, J., Zhang, Q., Diaz, G., Zieba, R., Thaisz, J., Drusco, A., Croce, C., Sadoshima, J., Condorelli, G., and Vatner, S.F. 2003. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem 278:47622-47628.

65.        Li, J., Yatani, A., Kim, S.J., Takagi, G., Irie, K., Zhang, Q., Karoor, V., Hong, C., Yang, G., Sadoshima, J., Depre, C., Vatner, D.E., West, M.J., and Vatner, S.F. 2003. Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy. Cardiovasc Res 59:
649-657.

64.        Morisco, C., Sadoshima, J., Trimarco, B., Arora, R., Vatner, D.E., and Vatner, S.F. 2003. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol 284:H1043-1047.

63.        Okumura, S., Kawabe, J., Yatani, A., Takagi, G., Lee, M.C., Hong, C., Liu, J., Takagi, I., Sadoshima, J., Vatner, D.E., Vatner, S.F., and Ishikawa, Y. 2003. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circ Res 93: 364-371.

62.        Okumura, S., Takagi, G., Kawabe, J., Yang, G., Lee, M.C., Hong, C., Liu, J., Vatner, D.E., Sadoshima, J., Vatner, S.F., and Ishikawa, Y. 2003. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci U S A 100:9986-9990.

61.        Seta, K., and Sadoshima, J. 2003. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem 278:9019-9026.

60.        Tomita, H., Nazmy, M., Kajimoto, K., Yehia, G., Molina, C.A., and Sadoshima, J. 2003. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circ Res 93:12-22.

59.        Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T., Vatner, S.F., and Sadoshima, J. 2003. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest 112:1395-1406.

58.        Yamamoto, S., Yang, G., Zablocki, D., Liu, J., Hong, C., Kim, S.J., Soler, S., Odashima, M., Thaisz, J., Yehia, G., Molina, C.A., Yatani, A., Vatner, D. E., Vatner, S.F., and Sadoshima, J. 2003. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest 111:1463-1474.

2002

57.        Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Russo, M.A., Gu, Y., Dalton, N., Chung, C., Latronico, M.V., Napoli, C., Sadoshima, J., Croce, C.M., and Ross, J., Jr. 2002. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.  Proc Natl Acad Sci U S A 99:12333-12338.

56.        Depre, C., Hase, M., Gaussin, V., Zajac, A., Wang, L., Hittinger, L., Ghaleh, B., Yu, X., Kudej, R.K., Wagner, T., Sadoshima, J., and Vatner, S.F. 2002. H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circ Res 91:1007-1014.

54.        Hardt, S.E., and Sadoshima, J. 2002. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res 90: 1055-1063.

54.        Sadoshima, J. 2002. Novel AT(1) receptor-independent functions of losartan. Circ Res 90:754-756.

53.        Sadoshima, J., Montagne, O., Wang, Q., Yang, G., Warden, J., Liu, J., Takagi, G., Karoor, V., Hong, C., Johnson, G.L., Vatner, D.E., and Vatner, S. F. 2002. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest 110:271-279.

52.        Seta, K., Nanamori, M., Modrall, J.G., Neubig, R.R., and Sadoshima, J. 2002. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol Chem 277:9268-9277.

51.        Seta, K., and Sadoshima, J. 2002. What is the unique function of SAPK3/p38gamma in cardiac myocytes? J Mol Cell Cardiol 34:597-600.

2001

50.        Modrall, J.G., Nanamori, M., Sadoshima, J., Barnhart, D.C., Stanley, J.C., and Neubig, R.R. 2001. ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling. Am J Physiol Cell Physiol 281:C801-809.

49.        Morisco, C., Seta, K., Hardt, S.E., Lee, Y., Vatner, S.F., and Sadoshima, J. 2001. Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J Biol Chem 276:28586-28597.

48.        Morisco, C., Zebrowski, D.C., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2001. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol 33:561-573.

47.        Yamamoto, S., Seta, K., Morisco, C., Vatner, S.F., and Sadoshima, J. 2001. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol 33:1829-1848.

46.        Yang, G., Meguro, T., Hong, C., Asai, K., Takagi, G., Karoor, V.L., Sadoshima, J., Vatner, D.E., Bishop, S.P., and Vatner, S.F. 2001. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. J Mol Cell Cardiol 33:1505-1514.

2000

45.        Aoki, H., Richmond, M., Izumo, S., and Sadoshima, J. 2000. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II- induced cardiac hypertrophy in vitro. Biochem J 347 Pt 1:275-284.

44.        Aoki, H., Sadoshima, J., and Izumo, S. 2000. Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro. Nat Med 6:183-188.

43.        Babu, G.J., Lalli, M.J., Sussman, M.A., Sadoshima, J., and Periasamy, M. 2000. Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol 32:1447-1457.

42.        Morisco, C., Zebrowski, D., Condorelli, G., Tsichlis, P., Vatner, S.F., and Sadoshima, J. 2000. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem 275:14466-14475.

41.        Sadoshima, J. 2000. Cytokine actions of angiotensin II. Circ Res 86:1187-1189.

1999

40.        Malhotra, R., Sadoshima, J., Brosius, F.C., 3rd, and Izumo, S. 1999. Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circ Res 85:137-146.

39.        Yamamoto, M., Okumura, S., Schwencke, C., Sadoshima, J., and Ishikawa, Y. 1999. High efficiency gene transfer by multiple transfection
protocol. Histochem J 31:241-243.

1998

38.        Aoki, H., Izumo, S., and Sadoshima, J. 1998. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 82:666-676.

37.        Sadoshima, J. 1998. Versatility of the angiotensin II type 1 receptor. Circ Res 82:1352-1355.

1997

36.        Sadoshima, J., Aoki, H., and Izumo, S. 1997. Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes. Circ Res 80:228-241.

35.        Sadoshima, J., and Izumo, S. 1997. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59:551-571.

34.        Sadoshima, J., and Izumo, S. 1997. Tyrosine kinases mediation of c-fos expression by cell swelling in cardiac myocytes. Heart Vessels Suppl 12:194-197.

33.        Todisco, A., Takeuchi, Y., Yamada, J., Sadoshima, J.I., and Yamada, T. 1997. Molecular mechanisms for somatostatin inhibition of c-fos gene expression. Am J Physiol 272:G721-726.

1996

32.        Jahn, L., Sadoshima, J., Greene, A., Parker, C., Morgan, K.G., and Izumo, S. 1996. Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. J Cell Sci 109 ( Pt 2):397-407.

31.        Sadoshima, J., and Izumo, S. 1996. Autocrine secretion of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Contrib Nephrol 118:214-221.

30.        Sadoshima, J., and Izumo, S. 1996. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. Embo J 15:775-787.

29.        Sadoshima, J., Malhotra, R., and Izumo, S. 1996. The role of the cardiac renin-angiotensin system in load-induced cardiac hypertrophy. J Card Fail 2:S1-6.

28.        Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1996. Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes. Embo J 15:5535-5546.

1995

27.        Sadoshima, J., and Izumo, S. 1995. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circ Res 77:1040-1052.

26.        Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1995. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circ Res 76:1-15.

25.        Schunkert, H., Sadoshima, J., Cornelius, T., Kagaya, Y., Weinberg, E.O., Izumo, S., Riegger, G., and Lorell, B.H. 1995. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res 76:489-497.

1994

24.        Jahn, L., Sadoshima, J., and Izumo, S. 1994. Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells. Exp Cell Res 212:297-307.

23.        Kai, H., Koyanagi, S., Hirooka, Y., Sugimachi, M., Sadoshima, J., Suzuki, S., and Takeshita, A. 1994. Right-to-left shunt across atrial septal defect related to tricuspid regurgitation: assessment by transesophageal Doppler echocardiography. Am Heart J 127:578-584.

1993

22.        Sadoshima, J., and Izumo, S. 1993. Mechanotransduction in stretch-induced hypertrophy of cardiac myocytes. J Recept Res 13:777-794.

21.        Sadoshima, J., and Izumo, S. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. Embo J 12:1681-1692.

20.        Sadoshima, J., and Izumo, S. 1993. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73:413-423.

19.        Sadoshima, J., and Izumo, S. 1993. Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res 73:424-438.

18.        Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75:977-984.

1992

17.        Sadoshima, J., Jahn, L., Takahashi, T., Kulik, T.J., and Izumo, S. 1992. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem 267:10551-10560.

16.        Sadoshima, J., Koyanagi, S., Sugimachi, M., Hirooka, Y., and Takeshita, A. 1992. Evaluation of the severity of mitral regurgitation by transesophageal Doppler flow echocardiography. Am Heart J 123:1245-1251.

15.        Sadoshima, J., Takahashi, T., Jahn, L., and Izumo, S. 1992. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci U S A 89:9905-9909.

1991

14.        Lai, C.P., Koyanagi, S., Sadoshima, J., Takeshita, A., and Tokunaga, K. 1991. Transesophageal echocardiographic findings of quadricuspid aortic valve. Jpn Heart J 32:731-734.

13.        Sadoshima, J., and Akaike, N. 1991. Kinetic properties of the caffeine-induced transient outward current in bull-frog sympathetic neurones. J Physiol 433:341-355.

1990

12.        Kuga, T., Sadoshima, J., Tomoike, H., Kanaide, H., Akaike, N., and Nakamura, M. 1990. Actions of Ca2+ antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res 67:469-480.

11.        Sadoshima, J., Oyama, Y., and Akaike, N. 1990. Inhibition of nicotinic acetylcholine response by atropine in frog isolated sympathetic neurons.  Brain Res 508:147-151.

1989

10.        Akaike, N., Kanaide, H., Kuga, T., Nakamura, M., Sadoshima, J., and Tomoike, H. 1989. Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture. J Physiol 416:141-160.

9.        Akaike, N., and Sadoshima, J. 1989. Caffeine affects four different ionic currents in the bull-frog sympathetic neurone. J Physiol 412:221-244.

8.        Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1989. Voltage-dependent anion-selective channels in cultured smooth muscle cells of the rat aorta. Comp Biochem Physiol A Comp Physiol 92:61-63.

1988

7.        Oyama, Y., Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Some properties of inhibitory action of lidocaine on the Ca2+ current of single isolated frog sensory neurons. Brain Res 442:223-228.

6.        Sadoshima, J., Akaike, N., Kanaide, H., and Nakamura, M. 1988. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. Am J Physiol 255:H754-759.

5.        Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1988. Ca-activated K channel in cultured smooth muscle cells of rat aortic media. Am J Physiol 255:H410-418.

4.        Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Effects of neostigmine and physostigmine on the acetylcholine receptor-ionophore complex in frog isolated sympathetic neurones. Br J Pharmacol 94:620-624.

1987

3.        Inoue, M., Sadoshima, J., and Akaike, N. 1987. Different actions of intracellular free calcium on resting and GABA-gated chloride conductances. Brain Res 404:301-303.

2.        Sadoshima, J., Nakashima, Y., Taira, Y., Koyanagi, S., Takeshita, A., Tanaka, K., and Nakamura, M. 1987. A case of primary dissecting aneurysm of the coronary artery. Jpn Heart J 28:799-804.

1.        Sadoshima, J., Taira, Y., Shimokawa, H., Koyanagi, S., Takeshita, A., and Nakamura, M. 1987. Two cases of dilated cardiomyopathy complicated by left ventricular aneurysm. Chest 92:377-379.1