Jun Sadoshima Pubmed Bibliography

1.         Hu C, Francisco J, Del Re DP and Sadoshima J. Decoding the Impact of the Hippo Pathway on Different Cell Types in Heart Failure. Circ J. 2024;

2.         Mareedu S, Fefelova N, Galindo CL, Prakash G, Mukai R, Sadoshima J, Xie LH and Babu GJ. Improved mitochondrial function in the heart of sarcolipin-deficient dystrophin and utrophin double knockout mice. JCI Insight. 2024;

3.         Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, et al. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy. 2024:1-34

4.         Kashihara T and Sadoshima J. Regulation of myocardial glucose metabolism by YAP/TAZ signaling. J Cardiol. 2024;83:323-329

5.         Greatorex S, Kaur S, Xirouchaki CE, Goh PK, Wiede F, Genders AJ, Tran M, Jia Y, Raajendiran A, Brown WA, et al. Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity. J Clin Invest. 2023;134.PMC10849767

6.         Zimmermann A, Madeo F, Diwan A, Sadoshima J, Sedej S, Kroemer G and Abdellatif M. Metabolic control of mitophagy. Eur J Clin Invest. 2024;54:e14138

7.         Vendrov AE, Xiao H, Lozhkin A, Hayami T, Hu G, Brody MJ, Sadoshima J, Zhang YY, Runge MS and Madamanchi NR. Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy. Redox Biol. 2023;67:102937.PMC10598408

8.         Gambardella J, Santulli G, Fiordelisi A, Cerasuolo FA, Wang X, Prevete N, Sommella E, Avvisato R, Buonaiuto A, Altobelli GG, et al. Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines. Cell Mol Life Sci. 2023;80:323.PMC10567889

9.         Titus AS, Sung EA, Zablocki D and Sadoshima J. Mitophagy for cardioprotection. Basic Res Cardiol. 2023;118:42.PMC10556134

10.       Mukai R and Sadoshima J. Ketone Bodies Preserve Mitochondria Through Epigenetics. JACC Basic Transl Sci. 2023;8:1138-1140.PMC10544105

11.       Nakamura M, Keller MA, Fefelova N, Zhai P, Liu T, Tian Y, Ikeda S, Del Re DP, Li H, Xie LH, et al. Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nat Commun. 2023;14:5805.PMC10509265

12.       Toro CA, De Gasperi R, Aslan A, Johnson N, Siddiq MM, Chow C, Zhao W, Harlow L, Graham Z, Liu XH, et al. Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice. bioRxiv. 2023.PMC10418279

13.       Schirone L, Vecchio D, Valenti V, Forte M, Relucenti M, Angelini A, Zaglia T, Schiavon S, D'Ambrosio L, Sarto G, et al. MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation. Cell Mol Life Sci. 2023;80:245.PMC10421787

14.       Francisco J, Guan J, Zhang Y, Nakada Y, Mareedu S, Sung EA, Hu CM, Oka S, Zhai P, Sadoshima J, et al. Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress. J Mol Cell Cardiol. 2023;181:1-14.PMC10524516

15.       Tong M, Mukai R, Mareedu S, Zhai P, Oka SI, Huang CY, Hsu CP, Yousufzai FAK, Fritzky L, Mizushima W, et al. Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy. Circ Res. 2023;133:6-21.PMC10330464

16.       Sadoshima J. Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts. Circulation. 2023;147:1180-1182.PMC10091234

17.       She G, Du JC, Wu W, Pu TT, Zhang Y, Bai RY, Zhang Y, Pang ZD, Wang HF, Ren YJ, et al. Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction. Theranostics. 2023;13:560-577.PMC9830444

18.       Abeliovich H, Debnath J, Ding WX, Jackson WT, Kim DH, Klionsky DJ, Ktistakis N, Margeta M, Munz C, Petersen M, et al. Where is the field of autophagy research heading? Autophagy. 2023;19:1049-1054.PMC10012950

19.       Oka SI, Titus AS, Zablocki D and Sadoshima J. Molecular properties and regulation of NAD(+) kinase (NADK). Redox Biol. 2023;59:102561.PMC9763689

20.       Nagarajan N, Oka SI, Nah J, Wu C, Zhai P, Mukai R, Xu X, Kashyap S, Huang CY, Sung EA, et al. Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia. J Clin Invest. 2023;133.PMC9888389

21.       Ketenci M, Zablocki D and Sadoshima J. Mitochondrial Quality Control Mechanisms during Diabetic Cardiomyopathy. JMA J. 2022;5:407-415.PMC9646286

22.       Sadoshima J. Editorial commentary: Targeting CLOCK: BMAL1 for treatment of ischemia/reperfusion injury. Trends Cardiovasc Med. 2024;34:8-9

23.       Motino O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montegut L, Chen H, Durand S, et al. ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis. Proc Natl Acad Sci U S A. 2022;119:e2207344119.PMC9565466

24.       Nah J, Zablocki D and Sadoshima J. The role of autophagic cell death in cardiac disease. J Mol Cell Cardiol. 2022;173:16-24

25.       Huang CY, Oka SI, Xu X, Chen CF, Tung CY, Chang YY, Mourad Y, Vehra O, Ivessa A, Yehia G, et al. PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARalpha and PGC-1alpha. Sci Rep. 2022;12:14576.PMC9418182

26.       Sadoshima J. Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of beta-hydroxybutyrate: implications in cardioprotection and aging. J Cardiovasc Aging. 2022;2.PMC9311383

27.       Matsushima S and Sadoshima J. Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion. Antioxidants (Basel). 2022;11.PMC9220061

28.       Jaijyan DK, Selariu A, Cruz-Cosme R, Tong M, Yang S, Stefa A, Kekich D, Sadoshima J, Herbig U, Tang Q, et al. New intranasal and injectable gene therapy for healthy life extension. Proc Natl Acad Sci U S A. 2022;119:e2121499119.PMC9171804

29.       Sadoshima J. TRAF2 Mediates Physiological Mitophagy. JACC Basic Transl Sci. 2022;7:244-246.PMC8993912

30.       Hale ZE and Sadoshima J. Primary Cilia and Their Role in Acquired Heart Disease. Cells. 2022;11.PMC8946116

31.       Maejima Y, Zablocki D, Nah J and Sadoshima J. The role of the Hippo pathway in autophagy in the heart. Cardiovasc Res. 2023;118:3320-3330.PMC10060713

32.       Kashihara T, Mukai R, Oka SI, Zhai P, Nakada Y, Yang Z, Mizushima W, Nakahara T, Warren JS, Abdellatif M, et al. YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload. J Clin Invest. 2022;132.PMC8920343

33.       Sciarretta S, Forte M and Sadoshima J. Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy? J Cardiovasc Aging. 2022;2.PMC8785976

34.       Nah J, Sung EA, Zhai P, Zablocki D and Sadoshima J. Tfeb-Mediated Transcriptional Regulation of Autophagy Induces Autosis during Ischemia/Reperfusion in the Heart. Cells. 2022;11.PMC8773671

35.       Sadoshima J. Alternative mitophagy is a major form of mitophagy in the chronically stressed heart. Autophagy. 2022;18:2252-2253.PMC9397446

36.       Nah J, Shirakabe A, Mukai R, Zhai P, Sung EA, Ivessa A, Mizushima W, Nakada Y, Saito T, Hu C, et al. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Cardiovasc Res. 2022;118:2638-2651.PMC10144728

37.       Sadoshima J. Myocardin-related transcription factor A in macrophages mediates pathological hypertrophy. Cardiovasc Res. 2022;118:662-663

38.       Ikeda S, Zablocki D and Sadoshima J. The role of autophagy in death of cardiomyocytes. J Mol Cell Cardiol. 2022;165:1-8.PMC8940676

39.       Xirouchaki CE, Jia Y, McGrath MJ, Greatorex S, Tran M, Merry TL, Hong D, Eramo MJ, Broome SC, Woodhead JST, et al. Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance. Sci Adv. 2021;7:eabl4988.PMC8673768

40.       Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re D and Sadoshima J. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Sci Rep. 2021;11:23469.PMC8648781

41.       Chen Y, Maejima Y, Shirakabe A, Yamamoto T, Ikeda Y, Sadoshima J and Zhai P. Ser9 phosphorylation of GSK-3beta promotes aging in the heart through suppression of autophagy. J Cardiovasc Aging. 2021;1.PMC8589323

42.       Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A and Sadoshima J. Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. Circ Res. 2021;129:1105-1121

43.       Sadoshima J. YAP Promotes Infarct Resolution by Stimulating Intercellular Signaling. Circ Res. 2021;129:798-800.PMC8514140

44.       Wu W, Ziemann M, Huynh K, She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, et al. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice. Theranostics. 2021;11:8993-9008.PMC8419046

45.       Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, et al. Autophagy in major human diseases. EMBO J. 2021;40:e108863.PMC8488577

46.       Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H and Lee CF. NAD(+) Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy. Circ Heart Fail. 2021;14:e008170.PMC8373812

47.       Oka SI, Tang F, Chin A, Ralda G, Xu X, Hu C, Yang Z, Abdellatif M and Sadoshima J. beta-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes. Antioxidants (Basel). 2021;10.PMC8301070

48.       Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T, Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, et al. Editors' Preamble to The Journal of Cardiovascular Aging. J Cardiovasc Aging. 2021;1.PMC8318349

49.       Mukai R and Sadoshima J. A Novel Inducer of Autophagy in the Heart. JACC Basic Transl Sci. 2021;6:381-383.PMC8093561

50.       Oka SI, Byun J, Huang CY, Imai N, Ralda G, Zhai P, Xu X, Kashyap S, Warren JS, Alan Maschek J, et al. Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy. Circ Res. 2021;129:114-130.PMC8513534

51.       Nah J, Zablocki D and Sadoshima J. The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death. Exp Mol Med. 2021;53:528-536.PMC8102471

52.       Fu P, Ramchandran R, Sudhadevi T, Kumar PPK, Krishnan Y, Liu Y, Zhao Y, Parinandi NL, Harijith A, Sadoshima J, et al. NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium. Antioxidants (Basel). 2021;10.PMC8002602

53.       Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J and Ohishi M. Estrogen Plays a Crucial Role in Rab9-Dependent Mitochondrial Autophagy, Delaying Arterial Senescence. J Am Heart Assoc. 2021;10:e019310.PMC8174372

54.       Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021;17:1-382.PMC7996087

55.       Sadoshima J, Kitsis RN and Sciarretta S. Editorial: Mitochondrial Dysfunction and Cardiovascular Diseases. Front Cardiovasc Med. 2021;8:645986.PMC7874211

56.       Kyriazis ID, Hoffman M, Gaignebet L, Lucchese AM, Markopoulou E, Palioura D, Wang C, Bannister TD, Christofidou-Solomidou M, Oka SI, et al. KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Circ Res. 2021;128:335-357.PMC7870005

57.       Sciarretta S, Forte M, Frati G and Sadoshima J. The complex network of mTOR signalling in the heart. Cardiovasc Res. 2022;118:424-439.PMC8932297

58.       Ikeda S, Nah J, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H and Sadoshima J. YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases. J Clin Invest. 2021;131.PMC7919732

59.       Saito T, Hamano K and Sadoshima J. Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart. Cardiovasc Res. 2021;117:2730-2741.PMC8932294

60.       Nakada Y and Sadoshima J. Sleep deficiency and mortality: is the solution in the gut? Cardiovasc Res. 2021;117:e26-e28.PMC8599891

61.       Venkatesh S, Baljinnyam E, Tong M, Kashihara T, Yan L, Liu T, Li H, Xie LH, Nakamura M, Oka SI, et al. Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells. Am J Physiol Regul Integr Comp Physiol. 2021;320:R547-R562.PMC8238141

62.       Sciarretta S, Forte M, Castoldi F, Frati G, Versaci F, Sadoshima J, Kroemer G and Maiuri MC. Caloric restriction mimetics for the treatment of cardiovascular diseases. Cardiovasc Res. 2021;117:1434-1449

63.       Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A, Yang Z, Abdellatif M and Sadoshima J. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Cardiovasc Res. 2021;117:2365-2376.PMC8861266

64.       Sciarretta S, Schirone L and Sadoshima J. Editorial commentary: How to implement research studies on extracellular vesicle administration in myocardial infarction. Trends Cardiovasc Med. 2021;31:416-418

65.       Nah J, Zablocki D and Sadoshima J. Autosis: A New Target to Prevent Cell Death. JACC Basic Transl Sci. 2020;5:857-869.PMC7452304

66.       Oka SI, Sabry AD, Horiuchi AK, Cawley KM, O'Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, et al. Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1. PLoS One. 2020;15:e0234913.PMC7310723

67.       Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, et al. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020;217.PMC7336299 Therapeutics, and Cygnal Therapeutics; grants from ONO and Fibrogen; personal fees from Chugai and Merck outside the submitted work; SAB, stock from Surface Oncology, Leap Therapeutics, and Cygnal Therapeutics; sponsored research from ONO and Fibrogen; and honoraria from Chugai and Merck. No other disclosures were reported.

68.       Nah J, Zhai P, Huang CY, Fernandez AF, Mareedu S, Levine B and Sadoshima J. Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury. J Clin Invest. 2020;130:2978-2991.PMC7260042

69.       Bellis A, Sorriento D, Fiordelisi A, Izzo R, Sadoshima J, Mauro C, Cerasuolo F, Mancusi C, Barbato E, Pilato E, et al. Autocrine Bradykinin Release Promotes Ischemic Preconditioning-Induced Cytoprotection in Bovine Aortic Endothelial Cells. Int J Mol Sci. 2020;21.PMC7215376

70.       Tong M, Zablocki D and Sadoshima J. The role of Drp1 in mitophagy and cell death in the heart. J Mol Cell Cardiol. 2020;142:138-145.PMC7545744

71.       Fernandez AF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, et al. Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. JCI Insight. 2020;5.PMC7030824

72.       Kashihara T and Sadoshima J. Role of YAP/TAZ in Energy Metabolism in the Heart. J Cardiovasc Pharmacol. 2019;74:483-490.PMC6905197

73.       Tong M and Sadoshima J. Nuclear miR-320 Controls Lipotoxicity. Circ Res. 2019;125:1121-1123.PMC8514138

74.       Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, et al. Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC Basic Transl Sci. 2019;4:611-622.PMC6872826

75.       Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019;11:e10469.PMC6835206

76.       Oka SI, Chin A, Park JY, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, et al. Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart. Cardiovasc Res. 2020;116:1742-1755.PMC7825501

77.       Kashihara T, Zablocki D and Sadoshima J. YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells. Biotarget. 2019;3.PMC6738959

78.       Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, et al. Dual peroxisome-proliferator-activated-receptor-alpha/gamma activation inhibits SIRT1-PGC1alpha axis and causes cardiac dysfunction. JCI Insight. 2019;5.PMC6777908

79.       Byun J, Oka SI, Imai N, Huang CY, Ralda G, Zhai P, Ikeda Y, Ikeda S and Sadoshima J. Both gain and loss of Nampt function promote pressure overload-induced heart failure. Am J Physiol Heart Circ Physiol. 2019;317:H711-H725.PMC6843022

80.       Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, et al. Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. Cell Death Dis. 2019;10:549.PMC6639386

81.       Francisco J, Byun J, Zhang Y, Kalloo OB, Mizushima W, Oka S, Zhai P, Sadoshima J and Del Re DP. The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium. J Biol Chem. 2019;294:13131-13144.PMC6721958

82.       Voigt N and Sadoshima J. Scientists on the Spot: Autophagy and heart disease. Cardiovasc Res. 2019;115:e91-e92.PMC8244630

83.       Nakamura M and Sadoshima J. Ketone body can be a fuel substrate for failing heart. Cardiovasc Res. 2019;115:1567-1569.PMC6704386

84.       Zhao WB, Lu Q, Nguyen MN, Su Y, Ziemann M, Wang LN, Kiriazis H, Puthalakath H, Sadoshima J, Hu HY, et al. Stimulation of beta-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway. Br J Pharmacol. 2019;176:2465-2481.PMC6592853

85.       Nakamura M and Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. J Physiol. 2020;598:2977-2993

86.       Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, et al. Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1alpha (Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1alpha) Dysregulation. Circ Heart Fail. 2019;12:e005529.PMC6392084

87.       Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, et al. Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca(2+)-ATPase in Heart Failure. Circ Res. 2019;124:e63-e80.PMC6483854

88.       Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A and Sadoshima J. Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy. Circ Res. 2019;124:1360-1371.PMC6483841

89.       Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019;10:651.PMC6381180 Therapeutics. The remaining authors declare no competing interests.

90.       Mukai R, Zablocki D and Sadoshima J. Intermittent Fasting Reverses an Advanced Form of Cardiomyopathy. J Am Heart Assoc. 2019;8:e011863.PMC6405682

91.       Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA, et al. Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration. Sci Rep. 2019;9:2002.PMC6376057

92.       Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, et al. Glycogen Synthase Kinase-3alpha Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019;29:1119-1134 e1112.PMC6677269

93.       Byun J, Del Re DP, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH and Sadoshima J. Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload. J Biol Chem. 2019;294:3603-3617.PMC6416448

94.       Venkatesh S, Li M, Saito T, Tong M, Rashed E, Mareedu S, Zhai P, Barcena C, Lopez-Otin C, Yehia G, et al. Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo. J Mol Cell Cardiol. 2019;128:38-50

95.       Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, et al. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019;124:292-305.PMC6645688

96.       Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, et al. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 2019;129:802-819.PMC6355232

97.       Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, et al. Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction. J Mol Cell Cardiol. 2019;126:1-12

98.       Nguyen MN, Ziemann M, Kiriazis H, Su Y, Thomas Z, Lu Q, Donner DG, Zhao WB, Rafehi H, Sadoshima J, et al. Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling. Am J Physiol Heart Circ Physiol. 2019;316:H45-H60

99.       Madrigal-Matute J, Scorrano L and Sadoshima J. Leducq Network: Modulating Autophagy to Treat Cardiovascular Disease. Circ Res. 2018;123:323-325.PMC6082024

100.     Nguyen MN, Su Y, Vizi D, Fang L, Ellims AH, Zhao WB, Kiriazis H, Gao XM, Sadoshima J, Taylor AJ, et al. Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure. Sci Rep. 2018;8:8213.PMC5973942

101.     Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, et al. Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction. J Am Coll Cardiol. 2018;71:1999-2010.PMC6347412

102.     Nakamura M and Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15:387-407

103.     Sauvat A, Chen G, Muller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, et al. Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine. 2018;30:261-272.PMC5952403

104.     Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, et al. Aspirin Recapitulates Features of Caloric Restriction. Cell Rep. 2018;22:2395-2407.PMC5848858

105.     Sciarretta S, Forte M, Frati G and Sadoshima J. New Insights Into the Role of mTOR Signaling in the Cardiovascular System. Circ Res. 2018;122:489-505.PMC6398933

106.     Tham YK, Huynh K, Mellett NA, Henstridge DC, Kiriazis H, Ooi JYY, Matsumoto A, Patterson NL, Sadoshima J, Meikle PJ, et al. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:219-234

107.     Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, et al. HAX-1 regulates SERCA2a oxidation and degradation. J Mol Cell Cardiol. 2018;114:220-233.PMC5801168

108.     Sadoshima J. Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School. Circ Res. 2017;121:1127-1129.PMC5762121

109.     Sciarretta S, Maejima Y, Zablocki D and Sadoshima J. The Role of Autophagy in the Heart. Annu Rev Physiol. 2018;80:1-26

110.     Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, et al. Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes. J Biol Chem. 2017;292:18988-19000.PMC5704480

111.     Nah J, Miyamoto S and Sadoshima J. Mitophagy as a Protective Mechanism against Myocardial Stress. Compr Physiol. 2017;7:1407-1424

112.     Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD and Tian R. Activation of gamma2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017;121:1182-1191.PMC5659937

113.     Sadoshima J and Tomoike H. What Should We Learn From the Recent Decline of Basic Cardiovascular Science in Japan? Circ Res. 2017;121:314-316.PMC5560069

114.     Mizushima W and Sadoshima J. BAG3 plays a central role in proteostasis in the heart. J Clin Invest. 2017;127:2900-2903.PMC5531392 exists.

115.     Huang C, Alapa M, Shu P, Nagarajan N, Wu C, Sadoshima J, Kholodovych V, Li H and Beuve A. Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1. J Biol Chem. 2017;292:14362-14370.PMC5582831

116.     Warren JS, Oka SI, Zablocki D and Sadoshima J. Metabolic reprogramming via PPARalpha signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics. Am J Physiol Heart Circ Physiol. 2017;313:H584-H596.PMC6425516

117.     Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, et al. Why publish in the American Journal of Physiology-Heart and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 2017;313:H221-H223

118.     Kang H, Oka S, Lee DY, Park J, Aponte AM, Jung YS, Bitterman J, Zhai P, He Y, Kooshapur H, et al. Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins. Nat Commun. 2017;8:15560.PMC5440690

119.     Byun S, Kim YC, Zhang Y, Kong B, Guo G, Sadoshima J, Ma J, Kemper B and Kemper JK. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769.PMC5470039

120.     Sciarretta S, De Falco E, Frati G and Sadoshima J. How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium. Ann Transl Med. 2017;5:52.PMC5326662

121.     Carrizzo A, Vecchione C, Damato A, di Nonno F, Ambrosio M, Pompeo F, Cappello E, Capocci L, Peruzzi M, Valenti V, et al. Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction. J Am Heart Assoc. 2017;6.PMC5524008

122.     Saito T and Sadoshima J. Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System. Circ Res. 2017;120:610-612.PMC5319734

123.     Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, et al. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017;8:14050.PMC5290275

124.     Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, et al. Dietary spermidine for lowering high blood pressure. Autophagy. 2017;13:767-769.PMC5381711

125.     Nagarajan N, Oka S and Sadoshima J. Modulation of signaling mechanisms in the heart by thioredoxin 1. Free Radic Biol Med. 2017;109:125-131.PMC5462876

126.     Hsu YJ, Hsu SC, Hsu CP, Chen YH, Chang YL, Sadoshima J, Huang SM, Tsai CS and Lin CY. Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. Int J Cardiol. 2017;228:543-552

127.     Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22:1428-1438.PMC5806691

128.     Nah J, Fernandez AF, Kitsis RN, Levine B and Sadoshima J. Does Autophagy Mediate Cardiac Myocyte Death During Stress? Circ Res. 2016;119:893-895.PMC5161244

129.     Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, et al. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J Clin Invest. 2016;126:3403-3416.PMC5004961

130.     Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B and Sadoshima J. Response by Shirakabe et al to Letter Regarding Article, "Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure". Circulation. 2016;134:e75-76.PMC5051345

131.     Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, Takeuchi O, Sadoshima J and Egashira K. Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction. J Am Heart Assoc. 2016;5.PMC5015412

132.     Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, et al. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ Res. 2016;119:596-606.PMC4992450

133.     Ikeda S and Sadoshima J. Regulation of Myocardial Cell Growth and Death by the Hippo Pathway. Circ J. 2016;80:1511-1519

134.     Bernardo BC, Ooi JY, Matsumoto A, Tham YK, Singla S, Kiriazis H, Patterson NL, Sadoshima J, Obad S, Lin RC, et al. Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs. J Physiol. 2016;594:5959-5974.PMC5063924

135.     Nakamura M, Zhai P, Del Re DP, Maejima Y and Sadoshima J. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight. 2016;1.PMC4869724

136.     Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK and Sadoshima J. Aging and Autophagy in the Heart. Circ Res. 2016;118:1563-1576.PMC4869999

137.     Tong M and Sadoshima J. Mitochondrial autophagy in cardiomyopathy. Curr Opin Genet Dev. 2016;38:8-15.PMC5028232

138.     Perez V, D'Annunzio V, Valdez LB, Zaobornyj T, Bombicino S, Mazo T, Carbajosa NL, Gironacci MM, Boveris A, Sadoshima J, et al. Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice. Antioxid Redox Signal. 2016;25:78-88

139.     Matsushima S, Zablocki D, Tsutsui H and Sadoshima J. Poldip2 negatively regulates matrix synthesis at focal adhesions. J Mol Cell Cardiol. 2016;94:10-12

140.     V DA, Perez V, Mazo T, Munoz MC, Dominici FP, Carreras MC, Poderoso JJ, Sadoshima J and Gelpi RJ. Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1. Oncotarget. 2016;7:11889-11898.PMC4914256

141.     Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B and Sadoshima J. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016;133:1249-1263.PMC4811679

142.     Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson AB, Kitsis RN and Sadoshima J. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. 2016;92:134-139

143.     Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, et al. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016;92:30-40.PMC5008453

144.     Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1-222.PMC4835977

145.     Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K and Kitazono T. Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. J Cereb Blood Flow Metab. 2016;36:1143-1154.PMC4908615

146.     Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J and Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015;89:185-194

147.     Maejima Y, Isobe M and Sadoshima J. Regulation of autophagy by Beclin 1 in the heart. J Mol Cell Cardiol. 2016;95:19-25.PMC4861696

148.     Sciarretta S, Boppana VS, Umapathi M, Frati G and Sadoshima J. Boosting autophagy in the diabetic heart: a translational perspective. Cardiovasc Diagn Ther. 2015;5:394-402.PMC4609904

149.     Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J and Shirokova N. Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy. Cardiovasc Res. 2015;108:324-334.PMC4648202

150.     Oka S, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP and Sadoshima J. Peroxisome Proliferator Activated Receptor-alpha Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart. Circ Heart Fail. 2015;8:1123-1132.PMC4651813

151.     Liu T, Wu C, Jain MR, Nagarajan N, Yan L, Dai H, Cui C, Baykal A, Pan S, Ago T, et al. Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta. 2015;1854:1816-1822.PMC4721509

152.     Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, et al. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 2015;117:891-904.PMC4747867

153.     Tzeng J, Byun J, Park JY, Yamamoto T, Schesing K, Tian B, Sadoshima J and Oka S. An Ideal PPAR Response Element Bound to and Activated by PPARalpha. PLoS One. 2015;10:e0134996.PMC4524655

154.     Matsushima S and Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375-1389.PMC4666968

155.     Ago T and Sadoshima J. From Contractile Enhancement to Pathological Hypertrophy: Angiotensin II-Induced Nox2-Mediated Reactive Oxygen Species. J Am Coll Cardiol. 2015;66:273-277

156.     Zablocki D and Sadoshima J. Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out. Circulation. 2015;131:2097-2100.PMC4470784

157.     Saito T and Sadoshima J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res. 2015;116:1477-1490.PMC4419704

158.     Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, et al. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep. 2015;11:125-136.PMC4417361

159.     Sciarretta S, Yee D, Ammann P, Nagarajan N, Volpe M, Frati G and Sadoshima J. Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes. Clin Sci (Lond). 2015;128:387-403

160.     Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, et al. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun. 2014;5:5705

161.     Nakamura M and Sadoshima J. Heart over mind: metabolic control of white adipose tissue and liver. EMBO Mol Med. 2014;6:1521-1524.PMC4287972

162.     Moyzis AG, Sadoshima J and Gustafsson AB. Mending a broken heart: the role of mitophagy in cardioprotection. Am J Physiol Heart Circ Physiol. 2015;308:H183-192.PMC4312945

163.     Maejima Y, Chen Y, Isobe M, Gustafsson AB, Kitsis RN and Sadoshima J. Recent progress in research on molecular mechanisms of autophagy in the heart. Am J Physiol Heart Circ Physiol. 2015;308:H259-268.PMC4329480

164.     Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116:264-278

165.     Chen L, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen RA and Tong X. Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines. Biochim Biophys Acta. 2014;1842:2489-2499

166.     Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M and Sadoshima J. Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system. J Mol Cell Cardiol. 2015;78:116-122.PMC4268018

167.     Hsu CP, Yamamoto T, Oka S and Sadoshima J. The function of nicotinamide phosphoribosyltransferase in the heart. DNA Repair (Amst). 2014;23:64-68.PMC4254158

168.     Maejima Y and Sadoshima J. SUMOylation: a novel protein quality control modifier in the heart. Circ Res. 2014;115:686-689.PMC4181369

169.     Wu C, Jain MR, Li Q, Oka S, Li W, Kong AN, Nagarajan N, Sadoshima J, Simmons WJ and Li H. Identification of novel nuclear targets of human thioredoxin 1. Mol Cell Proteomics. 2014;13:3507-3518.PMC4256501

170.     Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G and Sadoshima J. New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev. 2014;2014:210934.PMC4124219

171.     Wackerhage H, Del Re DP, Judson RN, Sudol M and Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Sci Signal. 2014;7:re4

172.     Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J and Guan KL. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014;5:4241.PMC4100214

173.     Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, et al. Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation. Hum Mol Genet. 2014;23:5706-5719.PMC4189904

174.     Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S and Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014;9:e98972.PMC4048236 does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. In addition, none of the authors have any potential competing interests.

175.     Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar RJ and Kho C. The role of SUMO-1 in cardiac oxidative stress and hypertrophy. Antioxid Redox Signal. 2014;21:1986-2001.PMC4208582

176.     Matsushima S, Tsutsui H and Sadoshima J. Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion. Trends Cardiovasc Med. 2014;24:202-205.PMC4119873

177.     Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP and Sadoshima J. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol Cell. 2014;54:639-650.PMC4074544

178.     Del Re DP and Sadoshima J. Elucidating ERK2 function in the heart. J Mol Cell Cardiol. 2014;72:336-338

179.     Sadoshima J and Weiss JN. Cardiac fibroblasts: the good, the bad, the ugly, the beautiful. J Mol Cell Cardiol. 2014;70:1.PMC4826044

180.     Maejima Y, Usui S, Zhai P, Takamura M, Kaneko S, Zablocki D, Yokota M, Isobe M and Sadoshima J. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A. Circ Heart Fail. 2014;7:479-490.PMC4031295

181.     Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D and Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315.PMC3962829

182.     Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H and Sadoshima J. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014;19:232-245.PMC3937768

183.     Sciarretta S, Volpe M and Sadoshima J. NOX4 regulates autophagy during energy deprivation. Autophagy. 2014;10:699-701.PMC4091158

184.     Sciarretta S, Volpe M and Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 2014;114:549-564.PMC3995130

185.     Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J and Tian R. Elimination of NADPH oxidase activity promotes reductive stress and sensitizes the heart to ischemic injury. J Am Heart Assoc. 2014;3:e000555.PMC3959718

186.     Sciarretta S, Yee D, Shenoy V, Nagarajan N and Sadoshima J. The importance of autophagy in cardioprotection. High Blood Press Cardiovasc Prev. 2014;21:21-28

187.     Zablocki D and Sadoshima J. Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection. Circ Res. 2013;113:1192-1195

188.     Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians ES and Benjamin IJ. Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system. Antioxid Redox Signal. 2014;20:2891-2906.PMC4039002

189.     Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J and Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest. 2013;123:5284-5297.PMC3859422

190.     Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013;19:1478-1488.PMC3823824

191.     Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M and Sadoshima J. Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2alpha/activating transcription factor 4 pathway. Circ Res. 2013;113:1253-1264.PMC3937770

192.     Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA, et al. DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3beta on eIF2Bepsilon. PLoS One. 2013;8:e70848.PMC3762802

193.     Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J and Hill JA. Cardiovascular autophagy: concepts, controversies, and perspectives. Autophagy. 2013;9:1455-1466

194.     Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, et al. C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling. Circ Res. 2013;112:1355-1364

195.     Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R and Sadoshima J. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1alpha and upregulation of peroxisome proliferator-activated receptor-alpha. Circ Res. 2013;112:1135-1149.PMC3871171

196.     Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J and Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arterioscler Thromb Vasc Biol. 2013;33:744-751.PMC3827725

197.     Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y and Sadoshima J. Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS One. 2013;8:e51632.PMC3538681 member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

198.     Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D, et al. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem. 2013;288:3977-3988.PMC3567650

199.     Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B and Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ Res. 2013;112:651-663.PMC3574183

200.     Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL and Lee Y. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7:e51621.PMC3517560

201.     Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8:445-544.PMC3404883

202.     Maejima Y, Galeotti J, Molkentin JD, Sadoshima J and Zhai P. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3alpha during aging and hemodynamic pressure overload. Am J Physiol Heart Circ Physiol. 2012;303:H979-988.PMC3774208

203.     Oka S, Hsu CP and Sadoshima J. Regulation of cell survival and death by pyridine nucleotides. Circ Res. 2012;111:611-627.PMC3523888

204.     Nakamura M, Bhatnagar A and Sadoshima J. Overview of pyridine nucleotides review series. Circ Res. 2012;111:604-610.PMC3523884

205.     Zschauer TC, Matsushima S, Altschmied J, Shao D, Sadoshima J and Haendeler J. Interacting with thioredoxin-1--disease or no disease? Antioxid Redox Signal. 2013;18:1053-1062.PMC3567779

206.     Sciarretta S, Zhai P, Volpe M and Sadoshima J. Pharmacological modulation of autophagy during cardiac stress. J Cardiovasc Pharmacol. 2012;60:235-241.PMC3514409

207.     Del Re DP and Sadoshima J. RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression. Mol Biol Int. 2012;2012:154283.PMC3337625

208.     Sciarretta S, Volpe M and Sadoshima J. Is reactivation of autophagy a possible therapeutic solution for obesity and metabolic syndrome? Autophagy. 2012;8:1252-1254.PMC3679239

209.     Del Re DP and Sadoshima J. Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circ Res. 2012;110:1154-1156.PMC3350802

210.     Zablocki D and Sadoshima J. Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal. 2013;19:1095-1109.PMC3771547

211.     Oka S, Zhai P, Alcendor R, Park JY, Tian B and Sadoshima J. Suppression of ERR targets by a PPARalpha/Sirt1 complex in the failing heart. Cell Cycle. 2012;11:856-864.PMC3323793

212.     Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G and Sadoshima J. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012;125:1134-1146.PMC3337789

213.     Messaoudi S, Zhang AD, Griol-Charhbili V, Escoubet B, Sadoshima J, Farman N and Jaisser F. The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. PLoS One. 2012;7:e30156.PMC3264592

214.     Zhai P and Sadoshima J. Glycogen synthase kinase-3beta controls autophagy during myocardial ischemia and reperfusion. Autophagy. 2012;8:138-139.PMC3335996

215.     Sadoshima J and Hare JM. Meeting report for Basic Cardiovascular Sciences 2011 Scientific Sessions: from concept to clinic: leading cardiovascular translational science. Circ Res. 2011;109:1204-1205

216.     Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B and Sadoshima J. PPARalpha-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab. 2011;14:598-611.PMC3217210

217.     Shao D, Oka S, Brady CD, Haendeler J, Eaton P and Sadoshima J. Redox modification of cell signaling in the cardiovascular system. J Mol Cell Cardiol. 2012;52:550-558.PMC3237398

218.     Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J and Tian B. Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS One. 2011;6:e22391.PMC3142162

219.     Zhai P, Sciarretta S, Galeotti J, Volpe M and Sadoshima J. Differential roles of GSK-3beta during myocardial ischemia and ischemia/reperfusion. Circ Res. 2011;109:502-511.PMC3158807

220.     Wu C, Parrott AM, Liu T, Jain MR, Yang Y, Sadoshima J and Li H. Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach. J Proteomics. 2011;74:2498-2509.PMC3253718

221.     Ago T, Kuroda J, Kamouchi M, Sadoshima J and Kitazono T. Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. -Review and perspective. Circ J. 2011;75:1791-1800

222.     Usui S, Maejima Y, Pain J, Hong C, Cho J, Park JY, Zablocki D, Tian B, Glass DJ and Sadoshima J. Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res. 2011;109:161-171.PMC3257317

223.     Del Re DP and Sadoshima J. Is Raf1 a nexus for cardiac hypertrophic signaling in human disease? J Mol Cell Cardiol. 2011;51:1-3

224.     Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, et al. Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011;15:2565-2604.PMC3176348

225.     Lin YR, Kim K, Yang Y, Ivessa A, Sadoshima J and Park Y. Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell. 2011;10:438-447

226.     Sadoshima J. Sirt3 targets mPTP and prevents aging in the heart. Aging (Albany NY). 2011;3:12-13.PMC3047131

227.     Zablocki D and Sadoshima J. Knocking out angiotensin II in the heart. Curr Hypertens Rep. 2011;13:129-135.PMC3278322

228.     Cho J, Zhai P, Maejima Y and Sadoshima J. Myocardial injection with GSK-3beta-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circ Res. 2011;108:478-489.PMC3109296

229.     Maejima Y, Kuroda J, Matsushima S, Ago T and Sadoshima J. Regulation of myocardial growth and death by NADPH oxidase. J Mol Cell Cardiol. 2011;50:408-416.PMC3257581

230.     Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T and Sadoshima J. The NADPH oxidase Nox4 and aging in the heart. Aging (Albany NY). 2010;2:1012-1016.PMC3034169

231.     Yamamoto T and Sadoshima J. Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med. 2011;21:27-32.PMC3326382

232.     Yang Y, Ago T, Zhai P, Abdellatif M and Sadoshima J. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res. 2011;108:305-313.PMC3249645

233.     Sciarretta S, Hariharan N, Monden Y, Zablocki D and Sadoshima J. Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol. 2011;32:275-281.PMC3261079

234.     Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, del Re D, Bhaumik M, Yehia G, Sadoshima J, et al. Injection of wild type embryonic stem cells into Mst1 transgenic blastocysts prevents adult-onset cardiomyopathy. Stem Cell Rev Rep. 2011;7:326-330.PMC3244830

235.     Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S and Sadoshima J. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010;122:2170-2182.PMC3003297

236.     Kajimoto K, Shao D, Takagi H, Maceri G, Zablocki D, Mukai H, Ono Y and Sadoshima J. Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011;300:H191-200.PMC3023260

237.     Matsushima S, Zablocki D and Sadoshima J. Application of recombinant thioredoxin1 for treatment of heart disease. J Mol Cell Cardiol. 2011;51:570-573.PMC3034160

238.     Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA and Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res. 2010;107:1470-1482.PMC3011986

239.     Del Re DP, Matsuda T, Zhai P, Gao S, Clark GJ, Van Der Weyden L and Sadoshima J. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest. 2010;120:3555-3567.PMC2947240

240.     Hariharan N, Zhai P and Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal. 2011;14:2179-2190.PMC3085947

241.     Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, et al. Dietary restriction: standing up for sirtuins. Science. 2010;329:1012-1013; author reply 1013-1014.PMC3985480

242.     Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD and Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A. 2010;107:15565-15570.PMC2932625

243.     Wu C, Liu T, Chen W, Oka S, Fu C, Jain MR, Parrott AM, Baykal AT, Sadoshima J and Li H. Redox regulatory mechanism of transnitrosylation by thioredoxin. Mol Cell Proteomics. 2010;9:2262-2275.PMC2953919

244.     Takagi H, Hsu CP, Kajimoto K, Shao D, Yang Y, Maejima Y, Zhai P, Yehia G, Yamada C, Zablocki D, et al. Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circ Res. 2010;107:642-649.PMC3081566

245.     Ago T, Yang Y, Zhai P and Sadoshima J. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. J Cardiovasc Transl Res. 2010;3:304-313.PMC3036765

246.     Kuroda J and Sadoshima J. NADPH oxidase and cardiac failure. J Cardiovasc Transl Res. 2010;3:314-320.PMC3257318

247.     Sciarretta S and Sadoshima J. New insights into the molecular phenotype of eccentric hypertrophy. J Mol Cell Cardiol. 2010;49:153-156.PMC2902863

248.     Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, et al. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010;2:26ra26.PMC3003709

249.     Zablocki D and Sadoshima J. The one-two punch: knocking out angiotensin II in the heart. J Clin Invest. 2010;120:1028-1031.PMC2846074

250.     Ago T, Kuroda J, Pain J, Fu C, Li H and Sadoshima J. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res. 2010;106:1253-1264.PMC2855780

251.     Chu PY, Mariani J, Finch S, McMullen JR, Sadoshima J, Marshall T and Kaye DM. Bone marrow-derived cells contribute to fibrosis in the chronically failing heart. Am J Pathol. 2010;176:1735-1742.PMC2843465

252.     Cho J, Rameshwar P and Sadoshima J. Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. J Biol Chem. 2009;284:36647-36658.PMC2794779

253.     Hsu CP, Hariharan N, Alcendor RR, Oka S and Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy. 2009;5:1229-1231

254.     Hu CL, Chandra R, Ge H, Pain J, Yan L, Babu G, Depre C, Iwatsubo K, Ishikawa Y, Sadoshima J, et al. Adenylyl cyclase type 5 protein expression during cardiac development and stress. Am J Physiol Heart Circ Physiol. 2009;297:H1776-1782.PMC2781380

255.     Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, Wong C, et al. Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria. J Mol Cell Cardiol. 2009;47:676-683

256.     Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LM, Ge H, Maejima Y, Donato M, Yokota M, et al. Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol. 2009;297:H1814-1819.PMC2781384

257.     Del Re DP and Sadoshima J. Optimizing cell-based therapy for cardiac regeneration. Circulation. 2009;120:831-834

258.     Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, et al. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am J Pathol. 2009;175:998-1009.PMC2731119

259.     Hsu CP, Oka S, Shao D, Hariharan N and Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 2009;105:481-491.PMC2765790

260.     Wu C, Yan L, Depre C, Dhar SK, Shen YT, Sadoshima J, Vatner SF and Vatner DE. Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction. Am J Physiol Cell Physiol. 2009;297:C928-934.PMC2770743

261.     Bellis A, Castaldo D, Trimarco V, Monti MG, Chivasso P, Sadoshima J, Trimarco B and Morisco C. Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late ischemic preconditioning. Arterioscler Thromb Vasc Biol. 2009;29:1207-1212

262.     Oka S, Ago T, Kitazono T, Zablocki D and Sadoshima J. The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy. J Mol Med (Berl). 2009;87:785-791

263.     Fu C, Wu C, Liu T, Ago T, Zhai P, Sadoshima J and Li H. Elucidation of thioredoxin target protein networks in mouse. Mol Cell Proteomics. 2009;8:1674-1687.PMC2709193

264.     Yan L, Sadoshima J, Vatner DE and Vatner SF. Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy. 2009;5:709-712

265.     Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF and Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879-886.PMC3332328

266.     Perry CN, Kyoi S, Hariharan N, Takagi H, Sadoshima J and Gottlieb RA. Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol. 2009;453:325-342.PMC3658837

267.     Vatner SF, Yan L, Ishikawa Y, Vatner DE and Sadoshima J. Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J. 2009;73:195-200

268.     Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, et al. Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A. 2008;105:20900-20905.PMC2634936

269.     Nishida K, Kyoi S, Yamaguchi O, Sadoshima J and Otsu K. The role of autophagy in the heart. Cell Death Differ. 2009;16:31-38

270.     Zhai P and Sadoshima J. Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. Circ Res. 2008;103:910-913.PMC2730891

271.     Shen YT, Depre C, Yan L, Park JY, Tian B, Jain K, Chen L, Zhang Y, Kudej RK, Zhao X, et al. Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation. 2008;118:1961-1969.PMC2634862

272.     Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, et al. Lats2 is a negative regulator of myocyte size in the heart. Circ Res. 2008;103:1309-1318.PMC2775813

273.     Fu C, Hu J, Liu T, Ago T, Sadoshima J and Li H. Quantitative analysis of redox-sensitive proteome with DIGE and ICAT. J Proteome Res. 2008;7:3789-3802.PMC2577071

274.     Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF and Sadoshima J. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 2008;133:978-993

275.     Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J and Sunagawa K. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008;28:1263-1269

276.     Sadoshima J. The role of autophagy during ischemia/reperfusion. Autophagy. 2008;4:402-403

277.     Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T, Vatner SF and Sadoshima J. Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy. 2008;4:409-415.PMC2708091

278.     Hsu CP, Odewale I, Alcendor RR and Sadoshima J. Sirt1 protects the heart from aging and stress. Biol Chem. 2008;389:221-231

279.     Morisco C, Marrone C, Galeotti J, Shao D, Vatner DE, Vatner SF and Sadoshima J. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc Res. 2008;78:36-44.PMC3031334

280.     Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008;4:151-175.PMC2654259

281.     Ohtsubo H, Ichiki T, Imayama I, Ono H, Fukuyama K, Hashiguchi Y, Sadoshima J and Sunagawa K. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells. Biochem Biophys Res Commun. 2008;367:474-480

282.     Hirotani S, Zhai P, Tomita H, Galeotti J, Marquez JP, Gao S, Hong C, Yatani A, Avila J and Sadoshima J. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res. 2007;101:1164-1174

283.     Zhai P, Gao S, Holle E, Yu X, Yatani A, Wagner T and Sadoshima J. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. J Biol Chem. 2007;282:33181-33191

284.     Morisco C, Marrone C, Trimarco V, Crispo S, Monti MG, Sadoshima J and Trimarco B. Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression. Cardiovasc Res. 2007;76:453-464

285.     Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J and Vatner SF. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell. 2007;130:247-258

286.     Takagi H, Matsui Y and Sadoshima J. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal. 2007;9:1373-1381

287.     Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T and Sadoshima J. AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy. 2007;3:405-407

288.     Ohtsubo H, Ichiki T, Miyazaki R, Inanaga K, Imayama I, Hashiguchi Y, Sadoshima J and Sunagawa K. Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell. Arterioscler Thromb Vasc Biol. 2007;27:1549-1555

289.     Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF and Vatner DE. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest. 2007;117:1335-1343.PMC1849986

290.     Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF and Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 2007;100:1512-1521

291.     Ago T and Sadoshima J. Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid Redox Signal. 2007;9:679-687

292.     Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M and Sadoshima J. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res. 2007;100:1344-1352

293.     Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B and Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007;100:914-922

294.     Nishizawa T, Shen YT, Rossi F, Hong C, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE and Vatner SF. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am J Physiol Heart Circ Physiol. 2007;292:H971-975

295.     Depre C, Wang Q, Yan L, Hedhli N, Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, et al. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation. 2006;114:1821-1828

296.     Ago T and Sadoshima J. Thioredoxin and ventricular remodeling. J Mol Cell Cardiol. 2006;41:762-773.PMC1852508

297.     Ago T, Yeh I, Yamamoto M, Schinke-Braun M, Brown JA, Tian B and Sadoshima J. Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart. Antioxid Redox Signal. 2006;8:1635-1650

298.     Sadoshima J. Redox regulation of growth and death in cardiac myocytes. Antioxid Redox Signal. 2006;8:1621-1624

299.     Liu J, Sadoshima J, Zhai P, Hong C, Yang G, Chen W, Yan L, Wang Y, Vatner SF and Vatner DE. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. J Mol Cell Cardiol. 2006;41:680-688

300.     Zhai P, Galeotti J, Liu J, Holle E, Yu X, Wagner T and Sadoshima J. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ Res. 2006;99:528-536

301.     Usui S, Yeh I, Tian B and Sadoshima J. Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research. J Mol Cell Cardiol. 2006;41:219-222

302.     Yan L, Sadoshima J, Vatner DE and Vatner SF. Autophagy: a novel protective mechanism in chronic ischemia. Cell Cycle. 2006;5:1175-1177

303.     Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006;281:21745-21754

304.     Chen IY, Lypowy J, Pain J, Sayed D, Grinberg S, Alcendor RR, Sadoshima J and Abdellatif M. Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol Chem. 2006;281:19369-19377

305.     Nishizawa T, Vatner SF, Hong C, Shen YT, Hardt SE, Robbins J, Ishikawa Y, Sadoshima J and Vatner DE. Overexpressed cardiac Gsalpha in rabbits. J Mol Cell Cardiol. 2006;41:44-50

306.     Ago T and Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 2006;98:294-297

307.     Zebrowski DC, Alcendor RR, Kirshenbaum LA and Sadoshima J. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. J Mol Cell Cardiol. 2006;40:605-618

308.     Zhai P, Yamamoto M, Galeotti J, Liu J, Masurekar M, Thaisz J, Irie K, Holle E, Yu X, Kupershmidt S, et al. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest. 2005;115:3045-3056.PMC1265872

309.     Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, et al. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A. 2005;102:14771-14776.PMC1253575

310.     Yan L, Vatner DE, Kim SJ, Ge H, Masurekar M, Massover WH, Yang G, Matsui Y, Sadoshima J and Vatner SF. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A. 2005;102:13807-13812.PMC1224362

311.     Hirotani S and Sadoshima J. Preconditioning effects of PKCdelta. J Mol Cell Cardiol. 2005;39:719-721

312.     Ono H, Ichiki T, Ohtsubo H, Fukuyama K, Imayama I, Hashiguchi Y, Sadoshima J and Sunagawa K. Critical role of Mst1 in vascular remodeling after injury. Arterioscler Thromb Vasc Biol. 2005;25:1871-1876

313.     Ding B, Abe JI, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, et al. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation. 2005;111:2469-2476.PMC4108189

314.     Hase M, Depre C, Vatner SF and Sadoshima J. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. Biochem J. 2005;388:475-483.PMC1138954

315.     Morisco C, Condorelli G, Trimarco V, Bellis A, Marrone C, Condorelli G, Sadoshima J and Trimarco B. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ Res. 2005;96:180-188

316.     Kim TG, Chen J, Sadoshima J and Lee Y. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004;24:10151-10160.PMC529025

317.     Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF and Sadoshima J. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res. 2004;95:971-980

318.     Hardt SE and Sadoshima J. Negative regulators of cardiac hypertrophy. Cardiovasc Res. 2004;63:500-509

319.     Matsui Y and Sadoshima J. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol. 2004;37:477-481

320.     Kawabe J, Okumura S, Lee MC, Sadoshima J and Ishikawa Y. Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2004;286:H1845-1852

321.     Hardt SE, Tomita H, Katus HA and Sadoshima J. Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy. Circ Res. 2004;94:926-935

322.     Karoor V, Vatner SF, Takagi G, Yang G, Thaisz J, Sadoshima J and Vatner DE. Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure. J Mol Cell Cardiol. 2004;36:305-312

323.     Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF and Sadoshima J. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest. 2003;112:1395-1406.PMC228400

324.     Li J, Yatani A, Kim SJ, Takagi G, Irie K, Zhang Q, Karoor V, Hong C, Yang G, Sadoshima J, et al. Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy. Cardiovasc Res. 2003;59:649-657

325.     Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, et al. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem. 2003;278:47622-47628

326.     Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, et al. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci U S A. 2003;100:9986-9990.PMC187910

327.     Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, et al. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circ Res. 2003;93:364-371

328.     Tomita H, Nazmy M, Kajimoto K, Yehia G, Molina CA and Sadoshima J. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circ Res. 2003;93:12-22

329.     Yamamoto S, Yang G, Zablocki D, Liu J, Hong C, Kim SJ, Soler S, Odashima M, Thaisz J, Yehia G, et al. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest. 2003;111:1463-1474.PMC155047

330.     Kim SJ, Peppas A, Hong SK, Yang G, Huang Y, Diaz G, Sadoshima J, Vatner DE and Vatner SF. Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circ Res. 2003;92:1233-1239

331.     Morisco C, Sadoshima J, Trimarco B, Arora R, Vatner DE and Vatner SF. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol. 2003;284:H1043-1047

332.     Seta K and Sadoshima J. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem. 2003;278:9019-9026

333.     Depre C, Hase M, Gaussin V, Zajac A, Wang L, Hittinger L, Ghaleh B, Yu X, Kudej RK, Wagner T, et al. H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circ Res. 2002;91:1007-1014

334.     Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A. 2002;99:12333-12338.PMC129445

335.     Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, et al. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest. 2002;110:271-279.PMC151048

336.     Seta K and Sadoshima J. What is the unique function of SAPK3/p38gamma in cardiac myocytes? J Mol Cell Cardiol. 2002;34:597-600

337.     Hardt SE and Sadoshima J. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res. 2002;90:1055-1063

338.     Sadoshima J. Novel AT(1) receptor-independent functions of losartan. Circ Res. 2002;90:754-756

339.     Seta K, Nanamori M, Modrall JG, Neubig RR and Sadoshima J. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol Chem. 2002;277:9268-9277

340.     Yamamoto S, Seta K, Morisco C, Vatner SF and Sadoshima J. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol. 2001;33:1829-1848

341.     Modrall JG, Nanamori M, Sadoshima J, Barnhart DC, Stanley JC and Neubig RR. ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling. Am J Physiol Cell Physiol. 2001;281:C801-809

342.     Yang G, Meguro T, Hong C, Asai K, Takagi G, Karoor VL, Sadoshima J, Vatner DE, Bishop SP and Vatner SF. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. J Mol Cell Cardiol. 2001;33:1505-1514

343.     Morisco C, Seta K, Hardt SE, Lee Y, Vatner SF and Sadoshima J. Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J Biol Chem. 2001;276:28586-28597

344.     Morisco C, Zebrowski DC, Vatner DE, Vatner SF and Sadoshima J. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol. 2001;33:561-573

345.     Babu GJ, Lalli MJ, Sussman MA, Sadoshima J and Periasamy M. Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol. 2000;32:1447-1457

346.     Sadoshima J. Cytokine actions of angiotensin II. Circ Res. 2000;86:1187-1189

347.     Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF and Sadoshima J. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem. 2000;275:14466-14475

348.     Aoki H, Richmond M, Izumo S and Sadoshima J. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J. 2000;347 Pt 1:275-284.PMC1220957

349.     Aoki H, Sadoshima J and Izumo S. Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro. Nat Med. 2000;6:183-188

350.     Yamamoto M, Okumura S, Schwencke C, Sadoshima J and Ishikawa Y. High efficiency gene transfer by multiple transfection protocol. Histochem J. 1999;31:241-243

351.     Malhotra R, Sadoshima J, Brosius FC, 3rd and Izumo S. Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circ Res. 1999;85:137-146

352.     Sadoshima J. Versatility of the angiotensin II type 1 receptor. Circ Res. 1998;82:1352-1355

353.     Aoki H, Izumo S and Sadoshima J. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res. 1998;82:666-676

354.     Todisco A, Takeuchi Y, Yamada J, Sadoshima JI and Yamada T. Molecular mechanisms for somatostatin inhibition of c-fos gene expression. Am J Physiol. 1997;272:G721-726

355.     Sadoshima J, Aoki H and Izumo S. Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes. Circ Res. 1997;80:228-241

356.     Sadoshima J and Izumo S. Tyrosine kinases mediation of c-fos expression by cell swelling in cardiac myocytes. Heart Vessels. 1997;Suppl 12:194-197

357.     Sadoshima J and Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol. 1997;59:551-571

358.     Sadoshima J, Malhotra R and Izumo S. The role of the cardiac renin-angiotensin system in load-induced cardiac hypertrophy. J Card Fail. 1996;2:S1-6

359.     Sadoshima J, Qiu Z, Morgan JP and Izumo S. Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes. EMBO J. 1996;15:5535-5546.PMC452298

360.     Sadoshima J and Izumo S. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J. 1996;15:775-787.PMC450276

361.     Jahn L, Sadoshima J, Greene A, Parker C, Morgan KG and Izumo S. Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. J Cell Sci. 1996;109 ( Pt 2):397-407

362.     Sadoshima J and Izumo S. Autocrine secretion of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Contrib Nephrol. 1996;118:214-221

363.     Sadoshima J and Izumo S. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circ Res. 1995;77:1040-1052

364.     Schunkert H, Sadoshima J, Cornelius T, Kagaya Y, Weinberg EO, Izumo S, Riegger G and Lorell BH. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res. 1995;76:489-497

365.     Sadoshima J, Qiu Z, Morgan JP and Izumo S. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circ Res. 1995;76:1-15

366.     Jahn L, Sadoshima J and Izumo S. Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells. Exp Cell Res. 1994;212:297-307

367.     Kai H, Koyanagi S, Hirooka Y, Sugimachi M, Sadoshima J, Suzuki S and Takeshita A. Right-to-left shunt across atrial septal defect related to tricuspid regurgitation: assessment by transesophageal Doppler echocardiography. Am Heart J. 1994;127:578-584

368.     Sadoshima J, Xu Y, Slayter HS and Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-984

369.     Sadoshima J and Izumo S. Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res. 1993;73:424-438

370.     Sadoshima J and Izumo S. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res. 1993;73:413-423

371.     Sadoshima J and Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 1993;12:1681-1692.PMC413382

372.     Sadoshima J and Izumo S. Mechanotransduction in stretch-induced hypertrophy of cardiac myocytes. J Recept Res. 1993;13:777-794

373.     Sadoshima J, Takahashi T, Jahn L and Izumo S. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci U S A. 1992;89:9905-9909.PMC50242

374.     Sadoshima J, Jahn L, Takahashi T, Kulik TJ and Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem. 1992;267:10551-10560

375.     Sadoshima J, Koyanagi S, Sugimachi M, Hirooka Y and Takeshita A. Evaluation of the severity of mitral regurgitation by transesophageal Doppler flow echocardiography. Am Heart J. 1992;123:1245-1251

376.     Lai CP, Koyanagi S, Sadoshima J, Takeshita A and Tokunaga K. Transesophageal echocardiographic findings of quadricuspid aortic valve. Jpn Heart J. 1991;32:731-734

377.     Sadoshima J and Akaike N. Kinetic properties of the caffeine-induced transient outward current in bull-frog sympathetic neurones. J Physiol. 1991;433:341-355.PMC1181374

378.     Kuga T, Sadoshima J, Tomoike H, Kanaide H, Akaike N and Nakamura M. Actions of Ca2+ antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res. 1990;67:469-480

379.     Sadoshima J, Oyama Y and Akaike N. Inhibition of nicotinic acetylcholine response by atropine in frog isolated sympathetic neurons. Brain Res. 1990;508:147-151

380.     Akaike N, Kanaide H, Kuga T, Nakamura M, Sadoshima J and Tomoike H. Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture. J Physiol. 1989;416:141-160.PMC1189208

381.     Akaike N and Sadoshima J. Caffeine affects four different ionic currents in the bull-frog sympathetic neurone. J Physiol. 1989;412:221-244.PMC1190572

382.     Sadoshima J, Akaike N, Tomoike H, Kanaide H and Nakamura M. Voltage-dependent anion-selective channels in cultured smooth muscle cells of the rat aorta. Comp Biochem Physiol A Comp Physiol. 1989;92:61-63

383.     Sadoshima J, Akaike N, Kanaide H and Nakamura M. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. Am J Physiol. 1988;255:H754-759

384.     Sadoshima J, Akaike N, Tomoike H, Kanaide H and Nakamura M. Ca-activated K channel in cultured smooth muscle cells of rat aortic media. Am J Physiol. 1988;255:H410-418

385.     Sadoshima J, Tokutomi N and Akaike N. Effects of neostigmine and physostigmine on the acetylcholine receptor-ionophore complex in frog isolated sympathetic neurones. Br J Pharmacol. 1988;94:620-624.PMC1853991

386.     Oyama Y, Sadoshima J, Tokutomi N and Akaike N. Some properties of inhibitory action of lidocaine on the Ca2+ current of single isolated frog sensory neurons. Brain Res. 1988;442:223-228

387.     Sadoshima J, Nakashima Y, Taira Y, Koyanagi S, Takeshita A, Tanaka K and Nakamura M. A case of primary dissecting aneurysm of the coronary artery. Jpn Heart J. 1987;28:799-804

388.     Sadoshima J, Taira Y, Shimokawa H, Koyanagi S, Takeshita A and Nakamura M. Two cases of dilated cardiomyopathy complicated by left ventricular aneurysm. Chest. 1987;92:377-379

389.     Inoue M, Sadoshima J and Akaike N. Different actions of intracellular free calcium on resting and GABA-gated chloride conductances. Brain Res. 1987;404:301-303

390.     Tsuji H, Murai K, Sadoshima J, Nagasawa K, Kajiwara E, Kobayashi K, Akagi K, Fujishima M, Sumiyoshi K and Beppu K. [An autopsied case of Budd-Chiari syndrome associated with multiple myeloma and amyloidosis]. Nihon Shokakibyo Gakkai Zasshi. 1986;83:688-692